Publication List

Paper#93: In vivo fertilization improved the cryotolerance and developmental ability of vitrified-warmed rat fertilized oocytes
Yuta Ishizuka, Satohiro Nakao, Tsutomu Kamisako, Katsuma Yamaga, Naomi Nakagata, Hiroyoshi Ishizaki, Toru Takeo
Scientific Reports, doi: https://doi.org/10.1038/s41598-024-76073-x(2024)

Paper#92: Ca2+-evoked sperm cessation determines embryo number in mammals.
Hitomi Watanabe, Daiya Ohara, Shinichiro Chuma, Yusuke Takeuchi, Tomoatsu Takano, Ami Katanaya, Satohiro Nakao, Akihisa Kaneko, Takatoku Oida, Tatsuya Katsuno, Takuya Uehata, Toru Takeo, Munehiro Okamoto, Keiji Hirota, Gen Kondoh
bioRxiv, doi: https://doi.org/10.1101/2024.09.16.613169(2024)

Paper#91: Uterine prostaglandin DP receptor induced upon implantation contributes to decidualization together with EP4 receptor
Sakamoto R, Fujiwara T, Kawano Y, Aikawa S, Inazumi T, Nakayama O, Kawasaki-Shirata Y, Hashimoto-Iwasaki M, Sugimoto T, Tsuchiya S, Nakao S, Takeo T, Hirota Y, Sugimoto Y
J Lipid Res, doi: https://doi.org/10.1016/j.jlr.2024.100636(2024)

Paper#90: Efficient breeding system of infertile Niemann-Pick disease type C model mice by in vitro fertilization and embryo transfer
Serina Kuroshima, Satohiro Nakao, Yuka Horikoshi, Kotono Ito, Akira Ishii, Aina Shirakawa, Yuki Kondo, Tetsumi Irie, Yoichi Ishitsuka, Naomi Nakagata, Toru Takeo
Laboratory Animals, doi: https://doi.org/10.1177/002367722311941(2024)

Paper#89: Improving laboratory animal genetic reporting: LAG-R guidelines
Lydia Teboul, James Amos-Landgraf, Fernando J. Benavides, Marie-Christine Birling, Steve D. M. Brown, Elizabeth Bryda, Rosie Bunton-Stasyshyn, Hsian-Jean Chin, Martina Crispo, Fabien Delerue, Michael Dobbie, Craig L. Franklin, Ernst-Martin Fuchtbauer, Xiang Gao, Christelle Golzio, Rebecca Haffner, Yann Hérault, Martin Hrabe de Angelis, Kevin C. Kent Lloyd, Terry R. Magnuson, Lluis Montoliu, Stephen A. Murray, Ki-Hoan Nam, Lauryl M. J. Nutter, Eric Pailhoux, Fernando Pardo Manuel de Villena, Kevin Peterson, Laura Reinholdt, Radislav Sedlacek, Je Kyung Seong, Toshihiko Shiroishi, Cynthia Smith, Toru Takeo, Louise Tinsley, Jean-Luc Vilotte, Søren Warming, Sara Wells, C. Bruce Whitelaw, Atsushi Yoshiki, Asian Mouse Mutagenesis Resource Association, CELPHEDIA infrastructure, INFRAFRONTIER consortium, International Mammalian Genome Society, International Mouse Phenotyping Consortium, International Society for Transgenic Technologies, Mutant Mouse Resource and Research Centers, Phenomics Australia, RRRC- Rat Resource and Research Center & Guillaume Pavlovic
Nature Communications, 15, 5574, doi: https://doi.org/10.1038/s41467-024-49439-y(2024)

Paper#88: Contribution of the α1-Acid Glycoprotein in Drug Pharmacokinetics: The Usefulness of α1-Acid Glycoprotein-Knockout Mice
Yuka Nakamura, Hiroshi Watanabe*, Tadashi Imafuku, Issei Fujita, Yuto Ganaha, Toru Takeo, Naomi Nakagata, Hitoshi Maeda, and Toru Maruyama
Mol. Pharmaceutics, doi: https://doi.org/10.1021/acs.molpharmaceut.3c00866(2024)

Paper#87: Intracerebroventricular 2-hydroxypropyl-γ-cyclodextrin alleviates hepatic manifestations without distributing to the liver in a murine model of Niemann-Pick disease type C
Yusei Yamada, Yoichi Ishitsuka, Madoka Fukaura-Nishizawa, Tatsuya Kawata, Akira Ishii, Aina Shirakawa, Taichi Sakai, Mayuko Tanaka, Yuki Kondo, Toru TAKEO, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Takahiro Seki, Yuki Kurauchi, Hiroshi Katsuki, Katsumi Higaki, Ryuji Ikeda, Muneaki Matsuo, Takumi Era, Tetsumi Irie
Life Sciences, 350, 122776, doi: https://doi.org/10.1016/j.lfs.2024.122776(2024)

Paper#86: GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates contractile force in mice
Rahmawati Aisyah, Noriyasu Ohshima, Daiki Watanabe, Yoshiko Nakagawa, Tetsushi Sakuma, Felix Nitschke, Minako Nakamura, Koji Sato, Kaori Nakahata, Chihiro Yokoyama, Charlotte R. Marchioni, Thanutchaporn Kumrungsee, Takahiko Shimizu, Yusuke Sotomaru, Toru TAKEO, Naomi Nakagata, Takashi Izumi, Shinji Miura, Berge A. Minassian, Takashi Yamamoto, Masanobu Wada, Noriyuki Yanaka
Commun Biol, 7, 604 doi: https://doi.org/10.1038/s42003-024-06298-z (2024)

Paper#85: High-concentration bovine serum albumin enhances fertilization ability of cold-stored rat sperm
Katsuma YAMAGA, Satohiro NAKAO, Nobuyuki MIKODA, Jorge Mario SZTEIN, Naomi NAKAGATA, Toru TAKEO
Journal of Reproduction and Development, 70(2), 131-137, doi: https://doi.org/10.1262/jrd.2023-085 (2024)

Paper#84: Time elapsed between ovulation and insemination determines the quality of fertilized rat oocytes
Naomi NAKAGATA, Satohiro NAKAO, Nobuyuki MIKODA, Katsuma YAMAGA, Toru TAKEO
Journal of Reproduction and Development, 70(2), 123-130, doi: https://doi.org/10.1262/jrd.2023-067 (2024)

Paper#83: Prostaglandin F2α Affects the Cycle of Clock Gene Expression and Mouse Behavior
Yuya Tsurudome, Yuya Yoshida, Kengo Hamamura, Takashi Ogino, Sai Yasukochi, Shinobu Yasuo, Ayaka Iwamoto, Tatsuya Yoshihara, Tomoaki Inazumi, Soken Tsuchiya, Toru Takeo, Naomi Nakagata, Shigekazu Higuchi, Yukihiko Sugimoto, Akito Tsuruta, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo
International Journal of Molecular Sciences, 25(3), 1841, doi: https://www.mdpi.com/2664960 (2024)

Paper#82: Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann-Pick disease type C treatment
Yusei Yamada, Madoka Fukaura-Nishizawa, Asami Nishiyama, Akira Ishii, Tatsuya Kawata, Aina Shirakawa, Mayuko Tanaka, Yuki Kondo, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Takahiro Seki, Yuki Kurauchi, Hiroshi Katsuki, Katsumi Higaki, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
Clinical and Translational Medicine, 13:e1350. doi: https://doi.org/10.1002/ctm2.1350 (2023)

Paper#81: Synchronization of the ovulation and copulation timings increased the number of in vivo fertilized oocytes in superovulated female mice
Satohiro Nakao, Kotono Ito, Chihiro Sugahara, Hitomi Watanabe, Gen Kondoh, Naomi Nakagata, Toru Takeo
PLoS One, 18(2): e0281330. doi: https://doi.org/10.1371/journal.pone.0281330 (2023)

Paper#80: Dimethyl-α-cyclodextrin induces capacitation by removing phospholipids from the plasma membrane of mouse sperm
Satohiro Nakao, Kotono Ito, Kazuhito Sakoh, Kenji Takemoto, Hitomi Watanabe, Gen Kondoh, Tetsumi Irie, Naomi Nakagata, Toru Takeo
Biology of Reproduction, 108(4), 671-681, doi: https://doi.org/10.1093/biolre/ioad013 (2023)

Paper#79: Observation of the in vitro fertilization process in living oocytes using frozen-thawed sperm in rats
Naomi Nakagata*, Satohiro Nakao*, Nobuyuki Mikoda, Katsuma Yamaga, Toru Takeo
Theriogenology, 199, 69-76, doi: 10.1016/j.theriogenology.2023.01.016. (2023) Observation of the in vitro fertilization process in living oocytes using frozen-thawed sperm in rats

Paper#78: Optimized protocols for sperm cryopreservation and in vitro fertilization in the rat
Takeo T, Nakao S, Mikoda N, Yamaga K, Maeda R, Tsuchiyama S, Nakatsukasa E, Nakagata N.
Lab Animal, 51(10):256-274. doi: 10.1038/s41684-022-01053-5. (2022) SharedIt Link（閲覧用）: https://rdcu.be/cXgma

Paper#77: Fine-tuned cholesterol solubilizer, mono-6-O-α-D-maltosyl-γ-cyclodextrin, ameliorates experimental Niemann-Pick disease type C without hearing loss
Yamada Y, Miwa T, Nakashima M, Shirakawa A, Ishii A, Namba N, Kondo Y, Takeo T, Nakagata N, Motoyama K, Higashi T, Arima H, Kurauchi Y, Seki T, Katsuki H, Okada Y, Ichikawa A, Higaki K, Hayashi K, Minami K, Yoshikawa N, Ikeda R, Ishikawa Y, Kajii T, Tachii K, Takeda H, Orita Y, Matsuo M, Irie T, Ishitsuka Y.
Biomed Pharmacother, 16;155:113698. doi: 10.1016/j.biopha.2022.113698.(2022)

Paper#76: Lactose-Appended Hydroxypropyl-β-Cyclodextrin Lowers Cholesterol Accumulation and Alleviates Motor Dysfunction in Niemann-Pick Type C Disease Model Mice
Takumi Nishida, Ryoma Yokoyama, Yuto Kubohira, Yuki Maeda, Toru Takeo, Naomi Nakagata, Hiroki Takagi, Kandai Ishikura, Kazunori Yanagihara, Shogo Misumi, Naoki Kishimoto, Yoichi Ishitsuka, Yuki Kondo, Tetsumi Irie, Minami Soga, Takumi Era, Risako Onodera, Taishi Higashi, and Keiichi Motoyama
ACS Appl. Bio Mater., https://doi.org/10.1021/acsabm.2c00233 (2022)

Paper#75: Androgen/Wnt/β-catenin signal axis augments cell proliferation of the mouse erectile tissue, corpus cavernosum
Mizuki Kajimoto, Kentaro Suzuki, Yuko Ueda, Kota Fujimoto, Toru Takeo, Naomi Nakagata, Taiju Hyuga, Kyoichi Isono, Gen Yamada
Congenital Anormalies, https://doi.org/10.1111/cga.12465 (2022)

Paper#74: Fine-Tuned Cholesterol Solubilizer, Mono-6-O-α-D-Maltosyl-γ-Cyclodextrin, Ameliorates Experimental Niemann-Pick Disease Type C Without Hearing Loss
Yusei Yamada, Toru Miwa, Masaki Nakashima, Aina Shirakawa, Nanami Namba, Yuki Kondo, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki, Yasuyo Okada, Atsushi Ichikawa, Katsumi Higaki, Ken Hayashi, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Yoshihide Ishikawa, Tomohito Kajii, Kyoko Tachii, Hiroki Takeda, Yorihisa Orita, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
SSRN, http://dx.doi.org/10.2139/ssrn.4037153 (2022)

Paper#73: Quercetin-treated rat sperm enables refrigerated transport with motility and fertility for five days
Katsuma Yamaga, Satohiro Nakao, Nobuyuki Mikoda, Hidetaka Yoshimoto, Ena Nakatsukasa, Naomi Nakagata, Toru Takeo
Scientific Reports, 11, 22641, https://doi.org/10.1038/s41598-021-02166-6 (2021)

Paper#72: Asian Mouse Mutagenesis Resource Association (AMMRA): mouse genetics and laboratory animal resources in the Asia Pacific
Hsian-Jean Chin, Michael S. Dobbie, Xiang Gao, James E. Hennessy, Ki-Hoan Nam, Je Kyung Seong, Toshihiko Shiroishi, Toru Takeo, Atsushi Yoshiki, Jing Zao & Chi-Kuang Leo Wang
Mammalian Genome, https://doi.org/10.1007/s00335-021-09912-1 (2021)

Paper#71: α1-acid glycoprotein enhances the immunosuppressive and protumor functions of tumor-associated macrophages
Kotaro Matsusaka, Yukio Fujiwara, Cheng Pan, Shigeyuki Esumi, Yoichi Saito, Jing Bi, Yuka Nakamura, Ayumi Mukunoki, Toru Takeo, Naomi Nakagata, Daiki Yoshii, Ryo Fukuda, Taisei Nagasaki, Ryusei Tanaka, Hisakazu Komori, Hitoshi Maeda, Hiroshi Watanabe, Koji Tamada, Yoshihiro Komohara and Toru Maruyama
Cancer Research, https://doi.10.1158/0008-5472.CAN-20-3471 (2021)

Paper#70: Sexual fate of murine external genitalia development: Conserved transcriptional competency for male-biased genes in both sexes
Daiki Kajioka, Kentaro Suzuki, Shoko Matsushita, Shinjiro Hino, Tetsuya Sato, Shuji Takada, Kyoichi Isono, Toru Takeo, Mizuki Kajimoto, Naomi Nakagata, Mitsuyoshi Nakao, Mikita Suyama, Tony DeFalco, Shinichi Miyagawa, and Gen Yamada
PNAS, https://doi.org/10.1073/pnas.2024067118 (2021)

Paper#69: Species Difference in Hydrolysis of an Ester-type Prodrug of Levodopa in Human and Animal Plasma: Different Contributions of Alpha-1 Acid Glycoprotein
Kenta Kono, Ken-ichi Nunoya, Yuka Nakamura, Jing Bi, Ayumi Mukunoki, Toru Takeo, Naomi Nakagata, Maeda Hitoshi, Yoshiyuki Yamaura, Haruo Imawaka, Hiroshi Watanabe, Toru Maruyama
Molecular Pharmaceutics, https://doi.org/10.1021/acs.molpharmaceut.0c01134 (2021)

Paper#68: An acute phase protein α 1-acid glycoprotein mitigates AKI and its progression to CKD through its anti-inflammatory action
Hiroshi Watanabe, Rui Fujimura, Yuto Hiramoto, Ryota Murata, Kento Nishida, Jing Bi, Tadashi Imafuku, Hisakazu Komori, Hitoshi Maeda, Ayumi Mukunoki, Toru Takeo, Naomi Nakagata, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa, Toru Maruyama Scientific Reports, PMID: 33846468 DOI: 10.1038/s41598-021-87217-8 (2021)

Paper#67: Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice
Naofumi Ito, M. Asrafuzzaman Riyadh, Shah Adil Ishtiyaq Ahmad, Satoko Hattori, Yonehiro Kanemura, Hiroshi Kiyonari, Takaya Abe, Yasuhide Furuta, Yohei Shinmyo, Naoko Kaneko, Yuki Hirota, Giuseppe Lupo, Jun Hatakeyama, Felemban Athary Abdulhaleem M, Mohammad Badrul Anam, Masahiro Yamaguchi, Toru Takeo, Hirohide Takebayashi, Minoru Takebayashi, Yuichi Oike, Naomi Nakagata, Kenji Shimamura, Michael J. Holtzman, Yoshiko Takahashi, Francois Guillemot, Tsuyoshi Miyakawa, Kazunobu Sawamoto, Kunimasa Ohta Science Translational Medicine, 13(587), eaay7896 - eaay7896 (2021)

Paper#66: Differential mode of cholesterol inclusion with 2‐hydroxypropyl‐cyclodextrins impacts safety margin in treating Niemann‐Pick disease type C
Yusei Yamada, Yoichi Ishitsuka, Yuki Kondo, Shuichi Nakahara, Asami Nishiyama, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Shunsuke Kamei, Tsuyoshi Shuto, Hirofumi Kai, Yuji Hayashino, Masatake Sugita, Takeshi Kikuchi, Fumio Hirata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Takahiro Seki, Tomoko Ohta, Yuki Kurauchi, Hiroshi Katsuki, Muneaki Matsuo, Katsumi Higaki, Kousaku Ohno, Shirou Matsumoto, Takumi Era, Tetsumi Irie
British Journal of Pharmacology, https://doi.org/10.1111/bph.15464 (2021)

Paper#65: Metformin ameliorates the severity of experimental Alport syndrome
Kohei Omachi, Shota Kaseda, Tsubasa Yokota, Misato Kamura, Keisuke Teramoto, Jun Kuwazuru, Haruka Kojima, Hirofumi Nohara, Kosuke Koyama, Sumio Ohtsuki, Shogo Misumi, Toru Takeo, Naomi Nakagata, Jian-Dong Li, Tsuyoshi Shuto, Mary Ann Suico, Jeffrey H. Miner, Hirofumi Kai
Scientific Reports, 11, Article number: 7053 (2021)

Paper#64: Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation
Yuichiro Arima*, Yoshiko Nakagawa*, Toru Takeo*, Toshifumi Ishida, Toshihiro Yamada, Shinjiro Hino, Mitsuyoshi Nakao, Sanshiro Hanada, Terumasa Umemoto, Toshio Suda, Tetsushi Sakuma, Takashi Yamamoto, Takehisa Watanabe, Katsuya Nagaoka, Yasuhito Tanaka, Yumiko K Kawamura, Kazuo Tonami, Hiroki Kurihara, Yoshifumi Sato, Kazuya Yamagata, Taishi Nakamura, Satoshi Araki, Eiichiro Yamamoto, Yasuhiro Izumiya, Kenji Sakamoto, Koichi Kaikita, Kenichi Matsushita, Koichi Nishiyama, Naomi Nakagata, and Kenichi Tsujita　 (*These authors equally contributed to this work.)
Nature Metabolism. 3, pages196-210 (2021)

Paper#63: Intracerebroventricular Treatment with 2-Hydroxypropyl-β-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann-Pick Disease Type C Model Mice
Madoka Fukaura, Yoichi Ishitsuka, Seiichi Shirakawa, Naoki Ushihama, Yusei Yamada, Yuki Kondo, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki, Katsumi Higaki, Muneaki Matsuo, Tetsumi Irie
International Journal of Molecular Sciences. 2021; 22(1):452.

Paper#62: Cryopreservation of mouse resources
Toru Takeo*, Satohiro Nakao, Yoshiko Nakagawa, Jorge M Sztein, Naomi Nakagata
Laboratory Animal Research, 36, Article number: 33, (2020)

Paper#61: Advanced oxidation protein products contribute to renal tubulopathy via perturbation of renal fatty acids
Tadashi Imafuku, Hiroshi Watanabe, Takao Satoh, Takashi Matsuzaka, Tomoaki Inazumi, Hiromasa Kato, Shoma Tanaka, Yuka Nakamura, Takehiro Nakano, Kai Tokumaru, Hitoshi Maeda, Ayumi Mukunoki, Toru Takeo, Naomi Nakagata, Motoko Tanaka, Kazutaka Matsushita, Soken Tsuchiya, Yukihiko Sugimoto, Hitoshi Shimano, Masafumi Fukagawa, and Toru Maruyama
Kidney360, 2020, 1, (8), 781-796

Paper#60: Simple transport and cryopreservation of cold-stored mouse embryos
Ayumi Mukunoki, Toru Takeo, Satohiro Nakao, Kana Tamura, Yuka Horikoshi, Naomi Nakagata
Experimental Animals, 69, 423-429, 2020

Paper#59: A synthetic retinoic acid receptor agonist Am80 ameliorates renal fibrosis via inducing the production of alpha-1-acid glycoprotein
Hiroshi Watanabe, Jing Bi, Ryota Murata, Rui Fujimura, Kento Nishida, Tadashi Imafuku, Yuka Nakamura, Hitoshi Maeda, Ayumi Mukunoki, Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa, Toru Maruyama
Scientific Reports, 10, Article number: 11424, 2020

Paper#58: Successful selection of mouse sperm with high viability and fertility using microfluidics chip cell sorter
Satohiro Nakao, Toru Takeo*, Hitomi Watanabe, Gen Kondoh, Naomi Nakagata
Scientific Reports, 10, Article number: 8862, 2020

Paper#57: Higher blood uric acid in female mice as a protective factor against pathophysiological decline of lung function
Haruka Fujikawa, Yuki Sakamoto, Natsuki Masuda, Kentaro Oniki, Shunsuke Kamei, Hirofumi Nohara, Ryunosuke Nakashima, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Noriki Takahashi, Toru Takeo, Naomi Nakagata, Hiroshi Watanabe, Koji Otake, Yasuhiro Ogata, Naoko H. Tomioka, Makoto Hosoyamada, Tappei Takada, Keiko Ueno-Shuto, Mary Ann Suico, Hirofumi Kai, Junji Saruwatari *, Tsuyoshi Shuto
Antioxidants, 9(5), 387, 2020

Paper#56: Efficient production of immunodeficient NOG mice via the superovulation technique using inhibin antiserum and gonadotropin
Motohito Goto, Toru Takeo, Riichi Takahashi, Naomi Nakagata
Laboratory Animals, 6, 23677220928091, 2020

Paper#55: Tsukushi is essential for the development of the inner ear
Toru Miwa, Kunimasa Ohta, Naofumi Ito, Satoko Hattori, Tsuyoshi Miyakawa, Toru Takeo, Naomi Nakagata, Wen-Jie Song, Ryosei Minoda
Molecular Brain 13(29), 2020

Paper#54: Azithromycin inhibits constitutive airway epithelial sodium channel activation in vitro and modulates downstream pathogenesis in vivo.
Haruka Fujikawa, Taise Kawakami, Ryunosuke Nakashima, Aoi Nasu, Shunsuke Kamei, Hirofumi Nohara, Yuka Eto, Keiko Ueno-Shuto, Toru Takeo, Naomi Nakagata, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto
Biological & pharmaceutical bulletin, 2020

Paper#53: Establishment of sperm cryopreservation and in vitro fertilisation protocols for rats
Naomi Nakagata, Nobuyuki Mikoda, Satohiro Nakao, Ena Nakatsukasa, Toru Takeo
Scientific Reports,10, 2020

Paper#52: N-acetyl cysteine restores the fertility of vitrified-warmed mouse oocytes derived through ultrasuperovulation
Mukunoki A, Takeo T, Nakagta N
PLoS One, 2019

Paper#51: Basic mouse reproductive techniques developed and modified at the Center for Animal Resources and Development (CARD), Kumamoto University
Nakagta N, Takeo T
Experimental Animals, 2019

Paper#50: Ovulation of juvenile, mature, and aged female C57BL/6 mice following coadministration of inhibin antiserum and equine chorionic gonadotropin
Toru Takeo, Ayumi Mukunoki, Naomi Nakagata
Theriogenology, 135, 1-6, 2019 Ovulation of juvenile, mature, and aged female C57BL/6 mice following coadministration of inhibin antiserum and equine chorionic gonadotropin

Paper#49: In vivo Efficacy and Safety Evaluation of Lactosyl-β-cyclodextrin as a Therapeutic Agent for Hepatomegaly in Niemann-Pick Type C Disease
Yuki Maeda, Keiichi Motoyama, Rena Nishiyama, Taishi Higashi, Risako Onodera, Hideaki Nakamura, Toru Takeo, Naomi Nakagata, Yusei Yamada, Yoichi Ishitsuka, Yuki Kondo, Tetsumi Irie, Takumi Era, Hidetoshi Arima
Nanomaterials, 9(5), 2019

Paper#48: Auto-measure emphysematous parameters and pathophysiological gene expression profiles in experimental mouse models of acute and chronic obstructive pulmonary diseases
Ryunosuke Nakashima, Shunsuke Kamei, Hirofumi Nohara, Haruka Fujikawa, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Noriki Takahashi, Mary Ann Suico, Toru Takeo, Naomi Nakagata, Hirofumi Kai, Tsuyoshi Shuto
Journal of Pharmacological Sciences, 140, 113-119, 2019

Paper#47: Mesenchymal actomyosin contractility is required for androgen-driven urethral masculinization in mice
Alvin R. Acebedo, Kentaro Suzuki, Shinjiro Hino, Mellissa C. Alcantara, Yuki Sato, Hisashi Haga, Ken-ichi Matsumoto, Mitsuyoshi Nakao, Kenji Shimamura, Toru Takeo, Naomi Nakagata, Shinichi Miyagawa, Ryuichi Nishinakamura, Robert S. Adelstein, Gen Yamada
Communications Biology, 2, 95, 2019

Paper#46: In Vitro and In Vivo Evaluation of 6-O-α-Maltosyl-β-Cyclodextrin as a Potential Therapeutic Agent Against Niemann-Pick Disease Type C
Nushrat Yasmin, Yoichi Ishitsuka, Madoka Fukaura, Yusei Yamada, Shuichi Nakahara, Akira Ishii, Yuki Kondo, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Yasuyo Okada, Junichi Nishikawa, Atsushi Ichikawa, Daisuke Iohara, Fumitoshi Hirayama, Katsumi Higaki, Kousaku Ohno, Muneaki Matsuo, Tetsumi Irie
International Journal of Molecular Sciences, 20(5), 1152, 2019

Paper#45: Bmp4 is an essential growth factor for the initiation of genital tubercle (GT) outgrowth
Kajioka D, Suzuki K, Nakada S, Matsushita S, Miyagawa S, Takeo T, Nakagata N, Yamada G
Congenital Anomalies, 60(1):15-21, 2019

Paper#44: Electroporation-mediated genome editing in vitrified/warmed mouse zygotes created by IVF via ultra-superovulation
Nakagawa Y, Sakuma T, Takeo T, Nakagata N, Yamamoto T
Experimental Animals, 67(4), 535-543, 2018

Paper#43: Lowering effect of dimethyl-α-cyclodextrin on GM1-ganglioside accumulation in GM1-gangliosidosis model cells and in brain of β-galactosidase-knockout mice
Yuki Maeda, Keiichi Motoyama, Taishi Higashi, Risako Onodera, Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Yoichi Ishitsuka, Yuki Kondo, Tetsumi Irie, Takumi Era, Hidetoshi Arima
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 93(1), 53-66, 2018

Paper#42: Mouse Sperm Cryopreservation Using Cryoprotectant Containing l-Glutamine.
Toru Takeo, Naomi Nakagata
Cold Spring Harb Protoc, 2018(6), 2018

Paper#41: In Vitro Fertilization in Mice
Toru Takeo, Naomi Nakagata
Cold Spring Harb Protocols, 2018(6), 2018

Paper#40: History of cryobiology, with special emphasis in evolution of mouse sperm cryopreservation
Jorge M Sztein, Toru Takeo, Naomi Nakagata
Cryobiology, 82, 57-63, 2018 History of cryobiology, with special emphasis in evolution of mouse sperm cryopreservation

Paper#39: STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model
Tsubasa Yokota, Kohei Omachi, Mary Ann Suico, Misato Kamura, Haruka Kojima, Ryosuke Fukuda, Keishi Motomura, Keisuke Teramoto, Shota Kaseda, Jun Kuwazuru, Toru Takeo, Naomi Nakagata, Tsuyoshi Shuto, Hirofumi Kai
Nephrology Dialysis Transplantation, 33(2), 214-223, 2018

Paper#38: Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells
Kamei S, Fujikawa H, Nohara H, Ueno-Shuto K, Maruta K, Nakashima R, Kawakami T, Matsumoto C, Sakaguchi Y, Ono T, Suico MA, Boucher RC, Gruenert DC, Takeo T, Nakagata N, Li JD, Kai H, Shuto T
EBioMedicine, 27, 304-316, 2018

Paper#37: Dimethyl sulfoxide and quercetin prolong the survival, motility, and fertility of cold-stored mouse sperm for 10 days
Hidetaka Yoshimoto, Toru Takeo, Naomi Nakagata
Biology of Reproduction, 97(6), 883-891, 2017

Paper#36: Culture time of vitrified/warmed zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice
Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Toru Takeo, Naomi Nakagata, Takashi Yamamoto
Biology Open,6(5), 706-713, 2017

Paper#35: Fertility of cold-stored mouse sperm is recovered by promoting acrosome reaction and hyperactivation after cholesterol efflux by methyl-β-cyclodextrin
Hidetaka Yoshimoto, Toru Takeo, Tetsumi Irie, Naomi Nakagata
Biology of Reproduction, 96(2), 446-455, 2017

Paper#34: Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases
Tsuyoshi Shuto, Shunsuke Kamei, Hirofumi Nohara, Haruka Fujikawa, Yukihiro Tasaki, Takuya Sugahara, Tomomi Ono, Chizuru Matsumoto, Yuki Sakaguchi, Kasumi Maruta, Ryunosuke Nakashima, Taisei Kawakami, Mary Ann Suico, Yoshitaka Kondo, Akihito Ishigami, Toru Takeo, Ken-ichiro Tanaka, Hiroshi Watanabe, Naomi Nakagata, Kohei Uchimura, Kenichiro Kitamura, Jian-Dong Li, Hirofumi Kai
Scientific Reports,6 , 39305, 2016

Paper#33: Immunotherapy using inhibin antiserum enhanced the efficacy of equine chorionic gonadotropin on superovulation in major inbred and outbred mice strains
Toru Takeo, Naomi Nakagata
Theriogenology, 86(5), 1341-1346, 2016 Immunotherapy using inhibin antiserum enhanced the efficacy of equine chorionic gonadotropin on superovulation in major inbred and outbred mice strains

Paper#32: Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single-amino-acid-substituted, and floxed mice
Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Noriyuki Yanaka, Toru Takeo, Naomi Nakagata, Takashi Yamamoto
Biology Open, 5(8), 1142-1148, 2016

Paper#31: N-acetyl cysteine prolonged the developmental ability of mouse two-cell embryos against oxidative stress at refrigerated temperatures
Yuka Horikoshi, Toru Takeo, Naomi Nakagata
Cryobiology,72(3),198-204, 2016 N-acetyl cysteine prolonged the developmental ability of mouse two-cell embryos against oxidative stress at refrigerated temperatures

Paper#30: GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development
Kazuhiko Kuwahara, Mutsuko Yamamoto-Ibusuki, Zhenhuan Zhang, Suchada Phimsen, Naomi Gondo, Hiroko Yamashita, Toru Takeo, Naomi Nakagata, Daisuke Yamashita, Yoshimi Fukushima, Yutaka Yamamoto, Hiroji Iwata, Hideyuki Saya, Eisaku Kondo, Keitaro Matsuo, Motohiro Takeya, Hirotaka Iwase, Nobuo Sakaguchi
Cancer Science, 107(4), 469-477, 2016

Paper#29: Feasibility study of cyclodextrins as active pharmaceutical ingredients for the treatment of GM1-gangliosidosis
Yuki Maeda, Keiichi Motoyama, Taishi Higashi, Yuka Horikoshi, Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Yuki Kondo, Yoichi Ishitsuka, Tetsumi Irie, Takumi Era, Hidetoshi Arima
Asian Journal of Pharmaceutical Sciences, 11(1), 183-184, 2015

Paper#28: Effects of Cyclodextrins on GM1-gangliosides in Fibroblasts from GM1-gangliosidosis Patients
Yuki Maeda, Keiichi Motoyama, Taishi Higashi, Yuka Horikoshi, Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Yuki Kondo, Yoichi Ishitsuka, Tetsumi Irie, Takumi Era, Hidetoshi Arima
Journal of Pharmacy and Pharmacology, 67(8), 1133-1142, 2015

Paper#27: El método CARD se consolida como el mejor protocolo de tecnología de la reproducción de ratón
Toru Takeo, Naomi Nakagata
Animales De Laboratorio, 65, 17-22, 2015

Paper#26: Superovulation Using the Combined Administration of Inhibin Antiserum and Equine Chorionic Gonadotropin Increases the Number of Ovulated Oocytes in C57BL/6 Female Mice
Toru Takeo, Naomi Nakagata
PLoS One, 10(5), 2015

Paper#25: Cysteine Analogs with a Free Thiol Group Promote Fertilization by Reducing Disulfide Bonds in the Zona Pellucida of Mice
Toru Takeo, Yuka Horikoshi, Satohiro Nakao, Kazuhito Sakoh, Yuta Ishizuka, Aki Tsutsumi, Kiyoko Fukumoto, Tomoko Kondo, Yukie Haruguchi, Yumi Takeshita, Yuko Nakamuta, Shuuji Tsuchiyama, Naomi Nakagata
Biology of Reproduction, 92(4), 90, 2015

Paper#24: Application of Cryotechnology to Establish Efficient Research Infrastructure for Genetically Engineered Mice
Toru Takeo, Naomi Nakagata
Cryobiology and Cryotechnology, 61(1), 19-26, 2015

Paper#23: Efficacy of 2-Hydroxypropyl-β-cyclodextrin in Niemann-Pick Disease Type C Model Mice and Its Pharmacokinetic Analysis in a Patient with the Disease
Yuta Tanaka, Yusei Yamada, Yoichi Ishitsuka, Muneaki Matsuo, Koki Shiraishi, Koki Wada, Yushiro Uchio, Yuki Kondo, Toru Takeo, Naomi Nakagata, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Sakiko Mochinaga, Katsumi Higaki, Kousaku Ohno, Tetsumi Irie
Biological & Pharmaceutical Bulletin, 38, 844-851, 2015

Paper#22: Conservation of Mouse Models Through Embryo Freezing
Mo Guan, Debora Bogani, Susan Marschall, Marcello Raspa, Toru Takeo, Naomi Nakagata, Martin Fray
Current Protocols in Mouse Biology, 4, 205-227, 2014

Paper#21: Prolonged exposure to hyaluronidase decreases the fertilization and development rates of fresh and cryopreserved mouse oocytes
Yuta Ishizuka, Toru Takeo, Satohiro Nakao, Hidetaka Yoshimoto, Yumiko Hirose, Yuki Sakai, Yuka Horikoshi, Shiori Takeuji, Shuuji Tsuchiyama, Naomi Nakagata
Journal of Reproduction and Development, 60(6), 454-459, 2014

Paper#20: Contemporary Techniques for Freezing Mouse Spermatozoa
Mo Guan, Debora Bogani, Susan Marschall, Marcello Raspa, Toru Takeo, Naomi Nakagata, Rob Taft, Martin Fray
Current Protocols in Mouse Biology, 4, 85-104, 2014

Paper#19: In Vitro Fertilization in Mice Using the MBCD-GSH Protocol
Mo Guan, Debora Bogani, Susan Marschall, Marcello Raspa, Toru Takeo, Naomi Nakagata, Martin Fray
Current Protocols in Mouse Biology, 4, 67-83, 2014

Paper#18: Transporting Mouse Embryos and Germplasm as Frozen or Unfrozen Materials
Janet Kenyon, Mo Guan, Debora Bogani, Susan Marschall, Marcello Raspa, Amanda Pickard, Toru Takeo, Naomi Nakagata, Martin Fray
Current Protocols in Mouse Biology, 4, 47-65, 2014

Paper#17: Lipocalin 2 binds to membrane phosphatidylethanolamine to induce lipid raft movement in a PKA-dependent manner and modulates sperm maturation
Hitomi Watanabe, Toru Takeo, Hiromasa Tojo, Kazuhito Sakoh, Thorsten Berger, Naomi Nakagata, Tak W. Mak, Gen Kondoh
Development, 141(10), 2157-2164, 2014

Paper#16: Rescue In Vitro Fertilization Method for Legacy Stock of Frozen Mouse Sperm
Naomi Nakagata, Toru Takeo, Kiyoko Fukumoto, Yukie Haruguchi, Tomoko Kondo, Yumi Takeshita, Yuko Nakamuta, Tomoko Umeno, Shuuji Tsuchiyama
Journal of Reproduction and Development, 60(2), 168-171, 2014

Paper#15: Investigations of motility and fertilization potential in thawed. cryopreserved mouse sperm from cold-stored epididymides
Toru Takeo, Kiyoko Fukumoto, Tomoko Kondo, Yukie Haruguchi, Yumi Takeshita, Yuko Nakamuta, Shuuji Tsuchiyama, Hidetaka Yoshimoto, Norihiko Shimizu, Ming-Wen Li, Kristy Kinchen, Jadine Vallelunga, K. C. Kent Lloyd, Naomi Nakagata
Cryobiology, 68(1), 12-17, 2014

Paper#14: Influence of Npc1 genotype on the toxicity of hydroxypropyl-β-cyclodextrin, a potentially therapeutic agent, in Niemann-Pick Type C disease models
Yuta Tanaka, Yoichi Ishitsuka, Yusei Yamada, Yuki Kondo, Toru Takeo, Naomi Nakagata, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Muneaki Matsuo, Katsumi Higaki, Kousaku Ohno, Tetsumi Irie
Molecular Genetics and Metabolism Reports, 1, 19-30, 2014 Influence of Npc1 genotype on the toxicity of hydroxypropyl-β-cyclodextrin, a potentially therapeutic agent, in Niemann-Pick Type C disease models

Paper#13: Applications of cryopreserved unfertilized mouse oocytes for in vitro fertilization
Naomi Nakagata, Toru Takeo, Kiyoko Fukumoto, Tomoko Kondo, Yukie Haruguchi, Yumi Takeshita, Yuko Nakamuta, Hiroko Matsunaga, Shuuji Tsuchiyama, Yuta Ishizuka, Kimi Araki
Cryobiology, 67(2), 188-192, 2013 Applications of cryopreserved unfertilized mouse oocytes for in vitro fertilization

Paper#12: The influence of fertility on in vitro matured C57BL/6 mouse oocytes by addition of reduced glutathione to fertilization medium
Yuta Ishizuka, Manami Nishimura, Kazuya Matsumoto, Minoru Miyashita, Toru Takeo, Naomi Nakagata, Yoshihiko Hosoi, Masayuki Anzai
Theriogenology, 80(5), 421-426, 2013 The influence of reduced glutathione in fertilization medium on the fertility of in vitro -matured C57BL/6 mouse oocytes

Paper#11: Establishment of a transport system for mouse epididymal sperm at refrigerated temperatures
Toru Takeo, Aki Tsutsumi, Taichi Omaru, Kiyoko Fukumoto, Yukie Haruguchi, Tomoko Kondo, Yuko Nakamuta, Yumi Takeshita, Hiroko Matsunaga, Shuuji Tsuchiyama, Kazuhito Sakoh, Satohiro Nakao, Hidetaka Yoshimoto, Norihiko Shimizu, Naomi Nakagata
Cryobiology, 65(3), 163-168, 2012 Establishment of a transport system for mouse epididymal sperm at refrigerated temperatures

Paper#10: Akt1-Mediated Skeletal Muscle Growth Attenuates Cardiac Dysfunction and Remodeling after Experimental Myocardial Infarction
Araki S, Izumiya Y, Hanatani S, Rokutanda T, Usuku H, Akasaki Y, Takeo T, Nakagata N, Walsh K, Ogawa H
Circulation. Heart failure, 5, 116-125, 2011

Paper#9: Novel migrating mouse neural crest cell assay system utilizing P0-Cre/EGFP fluorescent time-lapse imaging
Minoru Kawakami, Masafumi Umeda, Naomi Nakagata, Toru Takeo, Ken-ichi Yamamura
BMC Developmental Biology, 11, 68, 2011

Paper#8: Reduced Glutathione Enhances Fertility of Frozen/Thawed C57BL/6 Mouse Sperm after Exposure to Methyl-Beta-Cyclodextrin
Toru Takeo, Naomi Nakagata
Biology of Reproduction, 85(5), 1066-1072, 2011

Paper#7: Mouse sperm cryopreservation and effective embryo production using cryopreserved C57BL/6 mouse sperm
Toru Takeo, Naomi Nakagata
Journal of Mammalian Ova Research, 27(3), 70-78, 2010

Paper#6: Short-term storage and transport at cold temperatures of 2-cell mouse embryos produced by cryopreserved sperm
Toru Takeo, Kondo T, Haruguchi Y, Fukumoto K, Nakagawa Y, Takeshita Y, Nakamuta Y, Tsuchiyama S, Shimizu N, Hasegawa T, Goto M, Miyachi H, Anzai M, Fujikawa R, Nomaru K, Kaneko T, Itagaki Y, Nakagata N
Journal of the American Association for Laboratory Animal Science, 49, 415-419, 2010

Paper#5: Combination medium of cryoprotective agents containing L-glutamine and methyl-β-cyclodextrin in a preincubation medium yields a high fertilization rate for cryopreserved C57BL/6J mouse sperm
Toru Takeo, Naomi Nakagata
Laboratory Animals, 44(2), 132-137, 2010

Paper#4: Birth of mice from vitrified/warmed 2-cell embryos transported at a cold temperature
Takeo T, Kaneko T, Haruguchi Y, Fukumoto K, Machida H, Koga M, Nakagawa Y, Takeshita Y, Matsuguma T, Tsuchiyama S, Shimizu N, Hasegawa T, Goto M, Miyachi H, Anzai M, Nakatsukasa E, Nomaru K, Nakagata N
Cryobiology, 58(2), 196-202, 2009
Birth of mice from vitrified/warmed 2-cell embryos transported at a cold temperature

Paper#3: Methyl-beta-cyclodextrin improves fertilizing ability of C57BL/6 mouse sperm after freezing and thawing by facilitating cholesterol efflux from the cells
Takeo T, Hoshii T, Kondo Y, Toyodome H, Arima H, Yamamura K, Irie T, Nakagata N
Biology of Reproduction, 78(3), 546-551, 2008

Paper#2: LGR4 regulates the postnatal development and integrity of male reproductive tracts in mice
Hoshii T, Takeo T, Nakagata N, Takeya M, Araki K, Yamamura K
Biology of Reproduction, 76(2), 303-313, 2007

Paper#1: Decrease of Fertilizing Ability of Mouse Spermatozoa after Freezing and Thawing Is Related to Cellular Injury
Nishizono H, Shioda M, Takeo T, Irie T, Nakagata N
Biology of Reproduction, 71(3), 973-978, 2004

Dietary phytosterols induce infertility in female mice via epigenomic modulations.
Yoshihide Yamanashi, Toko Komine, Yasushi Hirota, Hiroshi Suzuki, Yutaka Osuga, Tappei Takada
Commun Biol 7, 1535 (2024).

Glyceraldehyde-derived advanced glycation end-products having pyrrolopyridinium-based crosslinks
Tomoaki Shigeta, Kazumi Sasamoto, Tetsuro Yamamoto
Biochemistry and Biophysics Reports, 26, 2021, 100963

A novel crosslinked type of advanced glycation end-product derived from lactaldehyde
Tomoaki Shigeta, Kazumi Sasamoto, Tetsuro Yamamoto
Helyon, Volume 6, Issue 11, November 2020, e05337