The genome sequences of various living organisms such as humans, chimpanzees, mice, chicken, and nematomorphs have been decoded. It is necessary to amass biological information such as expression analysis and system function analysis of genes, network analysis of genes or proteins to understand the mechanics of life. Genetically modified mice can be a powerful tool in gene function analysis at an individual level. Our aim is to clarify the vital functions of various genes by using genetically modified mice made by utilizing a genetic trap method as developed in the changeable genetic trap project. We have compiled a database of information on genetic trap clones and keep them as an open-resource to be used by all researchers. The Division of Bio-information is active in both fields; basic research of the life sciences and research support into bio resources.

The variable type genetic trap project is a collaborative research with the IRDA Division of Developmental Genetics.

1. Producing and analyzing diseased-model mice using the changeable genetic trap method.
2. Development and improvement of EGTC.
3. Database construction for promoter trap mice, which can be developed in needed areas.

• RIKEN BioResourse Center Development of Cre-driver mouse.
• Department of Orthopaedic Surgery, Faculty of Medicine, University of Miyazaki
  Screening of bone and cartilage disorder model mouse by using of the exchangeable gene trap system.

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• Shared facility Management of GTC
  Details => GTC HP
• Technical support and information service for gene testing.

• Support of Kumamoto University Living Modified Organism safety committee activities
• General education, cultural subject "Front line life science C"
• Graduate school of medical sciences, "Gene testing" is a part of "Organ genesis and regeneration medical theory"
• A part of lectures at School of medicine "General technology"
• School of Pharmacy Graduation work guidance
• School of Pharmacy Drug discovery "Bio information" "Bio information exercise
• Support to introduction of gene education at junior high schools and high schools.

• Study meeting (Research presentation, report of progress state)
• Experiment group meeting (Report of progress state)
• Journal club

• Molecular Biology Society of Japan, Japanese Society of Developmental Biologists, Japanese Association for Laboratory Animal Science

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