南敬教授の研究グループがダウン症の遺伝子による脂肪性肝炎の防護作用を発見
【研究のポイント】
【論文】
Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background
著者:Masashi Muramatsu,1¶ Tsuyoshi Osawa, 2¶ Yuri Miyamura, 1 Suguru Nakagawa,3 Toshiya Tanaka, 4 Tatsuhiko Kodama, 4 Hiroyuki Aburatani, 3 Juro Sakai, 5, 6 Sandra Ryeom,7 and Takashi Minami,1*
1 Div. Molecular and Vascular Biology, IRDA, Kumamoto University, 860-0811 Japan; 2 Div. Integrative Nutriomics, 3 Genome Science, 4 Systems Biology, and 5 Metabolic Medicine, RCAST, the University of Tokyo, 153-8904 Japan; 6 Div. of Molecular Physiology and Metabolism, Graduate School of Medicine, Tohoku University, 980-8575 Japan; and 7 Dept. Cancer Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA ¶: contributed equally
掲載誌:Journal of Biological Chemistry
URL:https://www.jbc.org/article/S0021-9258(21)00486-5/fulltext