資源開発分野Division of Reproductive Engineering
当分野では、生殖機能の制御に有用な化合物の探索、哺乳動物における繁殖、保存、輸送に有用な生殖工学技術に関する研究を行っています。
私達の研究成果として、精子凍結保存におけるL-グルタミンの凍結保護効果、体外受精におけるメチル-β-シクロデキストリンの精子に対する活性化作用、体外受精における還元型グルタチオンの卵子に対する受精機能向上効果、過剰排卵処理におけるインヒビン抗体とゴナドトロピンによる排卵数の向上効果、ジメチルスルフォオキサイドとケルセチンによる精子の冷蔵保護作用、N-アセチルシステインによる受精卵の冷蔵保護作用、凍結卵子を用いた体外受精におけるN-アセチルシステインによる受精能の回復効果、体外受精率の向上に有用な精子選抜法の開発に成功しています。
私たちの研究成果を社会へ還元するために、特許化および製品化にも取り組んでおり、科学技術の社会実装にも挑戦しています。
現在は、生殖工学技術のさらなる改良を目指し、有用化合物の探索、生殖に関する分子機構の解明、体外受精や胚移植の成功率向上に関する研究を進めております。
研究成果の詳細に関しては、下記の論文をご覧ください。
邦文雑誌・著書
マウスおよびラットにおける生殖工学研究
中尾聡宏, 山鹿優真, 中潟直己, 竹尾 透
月刊「細胞」 2023年1月
生殖細胞の新たな輸送手段としての冷蔵保存技術の有用性
山鹿 優真, 中尾聡宏, 竹尾 透
Bio Clinica 2021年12月
マウスおよびラット生殖工学技術の最前線
中尾 聡宏, 中潟 直己, 竹尾 透
Precision Medicine 2021年8月
2023
Paper#82: Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann-Pick disease type C treatment
Yusei Yamada, Madoka Fukaura-Nishizawa, Asami Nishiyama, Akira Ishii, Tatsuya Kawata, Aina Shirakawa, Mayuko Tanaka, Yuki Kondo,
Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Takahiro Seki, Yuki Kurauchi, Hiroshi Katsuki, Katsumi Higaki, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
Clinical and Translational Medicine, In Press doi:
https://doi.org/10.1002/ctm2.1350 (2023)
2022
Paper#77: Fine-tuned cholesterol solubilizer, mono-6-O-α-D-maltosyl-γ-cyclodextrin, ameliorates experimental Niemann-Pick disease type C without hearing loss
Yamada Y, Miwa T, Nakashima M, Shirakawa A, Ishii A, Namba N, Kondo Y,
Takeo T, Nakagata N, Motoyama K, Higashi T, Arima H, Kurauchi Y, Seki T, Katsuki H, Okada Y, Ichikawa A, Higaki K, Hayashi K, Minami K, Yoshikawa N, Ikeda R, Ishikawa Y, Kajii T, Tachii K, Takeda H, Orita Y, Matsuo M, Irie T, Ishitsuka Y.
Biomed Pharmacother, 16;155:113698. doi: 10.1016/j.biopha.2022.113698.(2022)
Paper#76: Lactose-Appended Hydroxypropyl-β-Cyclodextrin Lowers Cholesterol Accumulation and Alleviates Motor Dysfunction in Niemann-Pick Type C Disease Model Mice
Takumi Nishida, Ryoma Yokoyama, Yuto Kubohira, Yuki Maeda,
Toru Takeo, Naomi Nakagata, Hiroki Takagi, Kandai Ishikura, Kazunori Yanagihara, Shogo Misumi, Naoki Kishimoto, Yoichi Ishitsuka, Yuki Kondo, Tetsumi Irie, Minami Soga, Takumi Era, Risako Onodera, Taishi Higashi, and Keiichi Motoyama
ACS Appl. Bio Mater., https://doi.org/10.1021/acsabm.2c00233 (2022)
Paper#75: Androgen/Wnt/β-catenin signal axis augments cell proliferation of the mouse erectile tissue, corpus cavernosum
Mizuki Kajimoto, Kentaro Suzuki, Yuko Ueda, Kota Fujimoto,
Toru Takeo, Naomi Nakagata, Taiju Hyuga, Kyoichi Isono, Gen Yamada
Congenital Anormalies, https://doi.org/10.1111/cga.12465 (2022)
Paper#74: Fine-Tuned Cholesterol Solubilizer, Mono-6-O-α-D-Maltosyl-γ-Cyclodextrin, Ameliorates Experimental Niemann-Pick Disease Type C Without Hearing Loss
Yusei Yamada, Toru Miwa, Masaki Nakashima, Aina Shirakawa, Nanami Namba, Yuki Kondo,
Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki, Yasuyo Okada, Atsushi Ichikawa, Katsumi Higaki, Ken Hayashi, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Yoshihide Ishikawa, Tomohito Kajii, Kyoko Tachii, Hiroki Takeda, Yorihisa Orita, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
SSRN, http://dx.doi.org/10.2139/ssrn.4037153 (2022)
2021
Paper#72: Asian Mouse Mutagenesis Resource Association (AMMRA): mouse genetics and laboratory animal resources in the Asia Pacific
Hsian-Jean Chin, Michael S. Dobbie, Xiang Gao, James E. Hennessy, Ki-Hoan Nam, Je Kyung Seong, Toshihiko Shiroishi,
Toru Takeo, Atsushi Yoshiki, Jing Zao & Chi-Kuang Leo Wang
Mammalian Genome, https://doi.org/10.1007/s00335-021-09912-1 (2021)
Paper#71: α1-acid glycoprotein enhances the immunosuppressive and protumor functions of tumor-associated macrophages
Kotaro Matsusaka, Yukio Fujiwara, Cheng Pan, Shigeyuki Esumi, Yoichi Saito, Jing Bi, Yuka Nakamura, Ayumi Mukunoki,
Toru Takeo, Naomi Nakagata, Daiki Yoshii, Ryo Fukuda, Taisei Nagasaki, Ryusei Tanaka, Hisakazu Komori, Hitoshi Maeda, Hiroshi Watanabe, Koji Tamada, Yoshihiro Komohara and Toru Maruyama
Cancer Research, https://doi.10.1158/0008-5472.CAN-20-3471 (2021)
Paper#70: Sexual fate of murine external genitalia development: Conserved transcriptional competency for male-biased genes in both sexes
Daiki Kajioka, Kentaro Suzuki, Shoko Matsushita, Shinjiro Hino, Tetsuya Sato, Shuji Takada, Kyoichi Isono,
Toru Takeo, Mizuki Kajimoto, Naomi Nakagata, Mitsuyoshi Nakao, Mikita Suyama, Tony DeFalco, Shinichi Miyagawa, and Gen Yamada
PNAS, https://doi.org/10.1073/pnas.2024067118 (2021)
Paper#69: Species Difference in Hydrolysis of an Ester-type Prodrug of Levodopa in Human and Animal Plasma: Different Contributions of Alpha-1 Acid Glycoprotein
Kenta Kono, Ken-ichi Nunoya, Yuka Nakamura, Jing Bi, Ayumi Mukunoki,
Toru Takeo, Naomi Nakagata, Maeda Hitoshi, Yoshiyuki Yamaura, Haruo Imawaka, Hiroshi Watanabe, Toru Maruyama
Molecular Pharmaceutics, https://doi.org/10.1021/acs.molpharmaceut.0c01134 (2021)
Paper#68: An acute phase protein α 1-acid glycoprotein mitigates AKI and its progression to CKD through its anti-inflammatory action
Hiroshi Watanabe, Rui Fujimura, Yuto Hiramoto, Ryota Murata, Kento Nishida, Jing Bi, Tadashi Imafuku, Hisakazu Komori, Hitoshi Maeda, Ayumi Mukunoki,
Toru Takeo, Naomi Nakagata, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa, Toru Maruyama
Scientific Reports, PMID: 33846468 DOI: 10.1038/s41598-021-87217-8 (2021)
Paper#67: Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice
Naofumi Ito, M. Asrafuzzaman Riyadh, Shah Adil Ishtiyaq Ahmad, Satoko Hattori, Yonehiro Kanemura, Hiroshi Kiyonari, Takaya Abe, Yasuhide Furuta, Yohei Shinmyo, Naoko Kaneko, Yuki Hirota, Giuseppe Lupo, Jun Hatakeyama, Felemban Athary Abdulhaleem M, Mohammad Badrul Anam, Masahiro Yamaguchi,
Toru Takeo, Hirohide Takebayashi, Minoru Takebayashi, Yuichi Oike, Naomi Nakagata, Kenji Shimamura, Michael J. Holtzman, Yoshiko Takahashi, Francois Guillemot, Tsuyoshi Miyakawa, Kazunobu Sawamoto, Kunimasa Ohta
Science Translational Medicine, 13(587), eaay7896 - eaay7896 (2021)
Paper#66: Differential mode of cholesterol inclusion with 2‐hydroxypropyl‐cyclodextrins impacts safety margin in treating Niemann‐Pick disease type C
Yusei Yamada, Yoichi Ishitsuka, Yuki Kondo, Shuichi Nakahara, Asami Nishiyama,
Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Shunsuke Kamei, Tsuyoshi Shuto, Hirofumi Kai, Yuji Hayashino, Masatake Sugita, Takeshi Kikuchi, Fumio Hirata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Takahiro Seki, Tomoko Ohta, Yuki Kurauchi, Hiroshi Katsuki, Muneaki Matsuo, Katsumi Higaki, Kousaku Ohno, Shirou Matsumoto, Takumi Era, Tetsumi Irie
British Journal of Pharmacology, https://doi.org/10.1111/bph.15464 (2021)
Paper#65: Metformin ameliorates the severity of experimental Alport syndrome
Kohei Omachi, Shota Kaseda, Tsubasa Yokota, Misato Kamura, Keisuke Teramoto, Jun Kuwazuru, Haruka Kojima, Hirofumi Nohara, Kosuke Koyama, Sumio Ohtsuki, Shogo Misumi,
Toru Takeo, Naomi Nakagata, Jian-Dong Li, Tsuyoshi Shuto, Mary Ann Suico, Jeffrey H. Miner, Hirofumi Kai
Scientific Reports, 11, Article number: 7053 (2021)
Paper#64: Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation
Yuichiro Arima*, Yoshiko Nakagawa*,
Toru Takeo*, Toshifumi Ishida, Toshihiro Yamada, Shinjiro Hino, Mitsuyoshi Nakao, Sanshiro Hanada, Terumasa Umemoto, Toshio Suda, Tetsushi Sakuma, Takashi Yamamoto, Takehisa Watanabe, Katsuya Nagaoka, Yasuhito Tanaka, Yumiko K Kawamura, Kazuo Tonami, Hiroki Kurihara, Yoshifumi Sato, Kazuya Yamagata, Taishi Nakamura, Satoshi Araki, Eiichiro Yamamoto, Yasuhiro Izumiya, Kenji Sakamoto, Koichi Kaikita, Kenichi Matsushita, Koichi Nishiyama, Naomi Nakagata, and Kenichi Tsujita
(*These authors equally contributed to this work.)
Nature Metabolism. 3, pages196-210 (2021)
Paper#63: Intracerebroventricular Treatment with 2-Hydroxypropyl-β-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann-Pick Disease Type C Model Mice
Madoka Fukaura, Yoichi Ishitsuka, Seiichi Shirakawa, Naoki Ushihama, Yusei Yamada, Yuki Kondo,
Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki, Katsumi Higaki, Muneaki Matsuo, Tetsumi Irie
International Journal of Molecular Sciences. 2021; 22(1):452.
2020
Paper#62:
Cryopreservation of mouse resources
Toru Takeo*, Satohiro Nakao, Yoshiko Nakagawa, Jorge M Sztein, Naomi Nakagata
Laboratory Animal Research, 36, Article number: 33, (2020)
Paper#61:
Advanced oxidation protein products contribute to renal tubulopathy via perturbation of renal fatty acids
Tadashi Imafuku, Hiroshi Watanabe, Takao Satoh, Takashi Matsuzaka, Tomoaki Inazumi, Hiromasa Kato, Shoma Tanaka, Yuka Nakamura, Takehiro Nakano, Kai Tokumaru, Hitoshi Maeda, Ayumi Mukunoki,
Toru Takeo, Naomi Nakagata, Motoko Tanaka, Kazutaka Matsushita, Soken Tsuchiya, Yukihiko Sugimoto, Hitoshi Shimano, Masafumi Fukagawa, and Toru Maruyama
Kidney360, 2020, 1, (8), 781-796
Paper#59:
A synthetic retinoic acid receptor agonist Am80 ameliorates renal fibrosis via inducing the production of alpha-1-acid glycoprotein
Hiroshi Watanabe, Jing Bi, Ryota Murata, Rui Fujimura, Kento Nishida, Tadashi Imafuku, Yuka Nakamura, Hitoshi Maeda, Ayumi Mukunoki,
Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa, Toru Maruyama
Scientific Reports, 10, Article number: 11424, 2020
Paper#57:
Higher blood uric acid in female mice as a protective factor against pathophysiological decline of lung function
Haruka Fujikawa, Yuki Sakamoto, Natsuki Masuda, Kentaro Oniki, Shunsuke Kamei, Hirofumi Nohara, Ryunosuke Nakashima, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Noriki Takahashi,
Toru Takeo, Naomi Nakagata, Hiroshi Watanabe, Koji Otake, Yasuhiro Ogata, Naoko H. Tomioka, Makoto Hosoyamada, Tappei Takada, Keiko Ueno-Shuto, Mary Ann Suico, Hirofumi Kai, Junji Saruwatari *, Tsuyoshi Shuto
Antioxidants, 9(5), 387, 2020
Paper#54: Azithromycin inhibits constitutive airway epithelial sodium channel activation in vitro and modulates downstream pathogenesis in vivo.
Haruka Fujikawa, Taise Kawakami, Ryunosuke Nakashima, Aoi Nasu, Shunsuke Kamei, Hirofumi Nohara, Yuka Eto, Keiko Ueno-Shuto,
Toru Takeo, Naomi Nakagata, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto
Biological & pharmaceutical bulletin, 2020
2019
Paper#49: In vivo Efficacy and Safety Evaluation of Lactosyl-β-cyclodextrin as a Therapeutic Agent for Hepatomegaly in Niemann-Pick Type C Disease
Yuki Maeda, Keiichi Motoyama, Rena Nishiyama, Taishi Higashi, Risako Onodera, Hideaki Nakamura,
Toru Takeo, Naomi Nakagata, Yusei Yamada, Yoichi Ishitsuka, Yuki Kondo, Tetsumi Irie, Takumi Era, Hidetoshi Arima
Nanomaterials, 9(5), 2019
Paper#48: Auto-measure emphysematous parameters and pathophysiological gene expression profiles in experimental mouse models of acute and chronic obstructive pulmonary diseases
Ryunosuke Nakashima, Shunsuke Kamei, Hirofumi Nohara, Haruka Fujikawa, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Noriki Takahashi, Mary Ann Suico,
Toru Takeo, Naomi Nakagata, Hirofumi Kai, Tsuyoshi Shuto
Journal of Pharmacological Sciences, 140, 113-119, 2019
Paper#47: Mesenchymal actomyosin contractility is required for androgen-driven urethral masculinization in mice
Alvin R. Acebedo, Kentaro Suzuki, Shinjiro Hino, Mellissa C. Alcantara, Yuki Sato, Hisashi Haga, Ken-ichi Matsumoto, Mitsuyoshi Nakao, Kenji Shimamura,
Toru Takeo, Naomi Nakagata, Shinichi Miyagawa, Ryuichi Nishinakamura, Robert S. Adelstein, Gen Yamada
Communications Biology, 2, 95, 2019
Paper#46: In Vitro and In Vivo Evaluation of 6-O-α-Maltosyl-β-Cyclodextrin as a Potential Therapeutic Agent Against Niemann-Pick Disease Type C
Nushrat Yasmin, Yoichi Ishitsuka, Madoka Fukaura, Yusei Yamada, Shuichi Nakahara, Akira Ishii, Yuki Kondo,
Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Yasuyo Okada, Junichi Nishikawa, Atsushi Ichikawa, Daisuke Iohara, Fumitoshi Hirayama, Katsumi Higaki, Kousaku Ohno, Muneaki Matsuo, Tetsumi Irie
International Journal of Molecular Sciences, 20(5), 1152, 2019
2018
Paper#43: Lowering effect of dimethyl-α-cyclodextrin on GM1-ganglioside accumulation in GM1-gangliosidosis model cells and in brain of β-galactosidase-knockout mice
Yuki Maeda, Keiichi Motoyama, Taishi Higashi, Risako Onodera,
Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Yoichi Ishitsuka, Yuki Kondo, Tetsumi Irie, Takumi Era, Hidetoshi Arima
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 93(1), 53-66, 2018
Paper#39: STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model
Tsubasa Yokota, Kohei Omachi, Mary Ann Suico, Misato Kamura, Haruka Kojima, Ryosuke Fukuda, Keishi Motomura, Keisuke Teramoto, Shota Kaseda, Jun Kuwazuru,
Toru Takeo, Naomi Nakagata, Tsuyoshi Shuto, Hirofumi Kai
Nephrology Dialysis Transplantation, 33(2), 214-223, 2018
Paper#38: Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells
Kamei S, Fujikawa H, Nohara H, Ueno-Shuto K, Maruta K, Nakashima R, Kawakami T, Matsumoto C, Sakaguchi Y, Ono T, Suico MA, Boucher RC, Gruenert DC,
Takeo T, Nakagata N, Li JD, Kai H, Shuto T
EBioMedicine, 27, 304-316, 2018
2017
2016
Paper#34: Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases
Tsuyoshi Shuto, Shunsuke Kamei, Hirofumi Nohara, Haruka Fujikawa, Yukihiro Tasaki, Takuya Sugahara, Tomomi Ono, Chizuru Matsumoto, Yuki Sakaguchi, Kasumi Maruta, Ryunosuke Nakashima, Taisei Kawakami, Mary Ann Suico, Yoshitaka Kondo, Akihito Ishigami,
Toru Takeo, Ken-ichiro Tanaka, Hiroshi Watanabe, Naomi Nakagata, Kohei Uchimura, Kenichiro Kitamura, Jian-Dong Li, Hirofumi Kai
Scientific Reports,6 , 39305, 2016
Paper#32: Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single-amino-acid-substituted, and floxed mice
Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Noriyuki Yanaka,
Toru Takeo, Naomi Nakagata, Takashi Yamamoto
Biology Open, 5(8), 1142-1148, 2016
Paper#30: GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development
Kazuhiko Kuwahara, Mutsuko Yamamoto-Ibusuki, Zhenhuan Zhang, Suchada Phimsen, Naomi Gondo, Hiroko Yamashita,
Toru Takeo, Naomi Nakagata, Daisuke Yamashita, Yoshimi Fukushima, Yutaka Yamamoto, Hiroji Iwata, Hideyuki Saya, Eisaku Kondo, Keitaro Matsuo, Motohiro Takeya, Hirotaka Iwase, Nobuo Sakaguchi
Cancer Science, 107(4), 469-477, 2016
2015
Paper#29: Feasibility study of cyclodextrins as active pharmaceutical ingredients for the treatment of GM1-gangliosidosis
Yuki Maeda, Keiichi Motoyama, Taishi Higashi, Yuka Horikoshi,
Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Yuki Kondo, Yoichi Ishitsuka, Tetsumi Irie, Takumi Era, Hidetoshi Arima
Asian Journal of Pharmaceutical Sciences, 11(1), 183-184, 2015
Paper#28: Effects of Cyclodextrins on GM1-gangliosides in Fibroblasts from GM1-gangliosidosis Patients
Yuki Maeda, Keiichi Motoyama, Taishi Higashi, Yuka Horikoshi,
Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Yuki Kondo, Yoichi Ishitsuka, Tetsumi Irie, Takumi Era, Hidetoshi Arima
Journal of Pharmacy and Pharmacology, 67(8), 1133-1142, 2015
Paper#27: El método CARD se consolida como el mejor protocolo de tecnología de la reproducción de ratón
Toru Takeo, Naomi Nakagata
Animales De Laboratorio, 65, 17-22, 2015
Paper#25: Cysteine Analogs with a Free Thiol Group Promote Fertilization by Reducing Disulfide Bonds in the Zona Pellucida of Mice
Toru Takeo, Yuka Horikoshi, Satohiro Nakao, Kazuhito Sakoh, Yuta Ishizuka, Aki Tsutsumi, Kiyoko Fukumoto, Tomoko Kondo, Yukie Haruguchi, Yumi Takeshita, Yuko Nakamuta, Shuuji Tsuchiyama, Naomi Nakagata
Biology of Reproduction, 92(4), 90, 2015
.
Paper#23: Efficacy of 2-Hydroxypropyl-β-cyclodextrin in Niemann-Pick Disease Type C Model Mice and Its Pharmacokinetic Analysis in a Patient with the Disease
Yuta Tanaka, Yusei Yamada, Yoichi Ishitsuka, Muneaki Matsuo, Koki Shiraishi, Koki Wada, Yushiro Uchio, Yuki Kondo,
Toru Takeo, Naomi Nakagata, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Sakiko Mochinaga, Katsumi Higaki, Kousaku Ohno, Tetsumi Irie
Biological & Pharmaceutical Bulletin, 38, 844-851, 2015
2014
Paper#21: Prolonged exposure to hyaluronidase decreases the fertilization and development rates of fresh and cryopreserved mouse oocytes
Yuta Ishizuka,
Toru Takeo, Satohiro Nakao, Hidetaka Yoshimoto, Yumiko Hirose, Yuki Sakai, Yuka Horikoshi, Shiori Takeuji, Shuuji Tsuchiyama, Naomi Nakagata
Journal of Reproduction and Development, 60(6), 454-459, 2014
Paper#20: Contemporary Techniques for Freezing Mouse Spermatozoa
Mo Guan, Debora Bogani, Susan Marschall, Marcello Raspa,
Toru Takeo, Naomi Nakagata, Rob Taft, Martin Fray
Current Protocols in Mouse Biology, 4, 85-104, 2014
Paper#18: Transporting Mouse Embryos and Germplasm as Frozen or Unfrozen Materials
Janet Kenyon, Mo Guan, Debora Bogani, Susan Marschall, Marcello Raspa, Amanda Pickard,
Toru Takeo, Naomi Nakagata, Martin Fray
Current Protocols in Mouse Biology, 4, 47-65, 2014
Paper#17: Lipocalin 2 binds to membrane phosphatidylethanolamine to induce lipid raft movement in a PKA-dependent manner and modulates sperm maturation
Hitomi Watanabe,
Toru Takeo, Hiromasa Tojo, Kazuhito Sakoh, Thorsten Berger, Naomi Nakagata, Tak W. Mak, Gen Kondoh
Development, 141(10), 2157-2164, 2014
Paper#16: Rescue In Vitro Fertilization Method for Legacy Stock of Frozen Mouse Sperm
Naomi Nakagata,
Toru Takeo, Kiyoko Fukumoto, Yukie Haruguchi, Tomoko Kondo, Yumi Takeshita, Yuko Nakamuta, Tomoko Umeno, Shuuji Tsuchiyama
Journal of Reproduction and Development, 60(2), 168-171, 2014
Paper#15: Investigations of motility and fertilization potential in thawed. cryopreserved mouse sperm from cold-stored epididymides
Toru Takeo, Kiyoko Fukumoto, Tomoko Kondo, Yukie Haruguchi, Yumi Takeshita, Yuko Nakamuta, Shuuji Tsuchiyama, Hidetaka Yoshimoto, Norihiko Shimizu, Ming-Wen Li, Kristy Kinchen, Jadine Vallelunga, K. C. Kent Lloyd, Naomi Nakagata
Cryobiology, 68(1), 12-17, 2014
Paper#14: Influence of Npc1 genotype on the toxicity of hydroxypropyl-β-cyclodextrin, a potentially therapeutic agent, in Niemann-Pick Type C disease models
Yuta Tanaka, Yoichi Ishitsuka, Yusei Yamada, Yuki Kondo,
Toru Takeo, Naomi Nakagata, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Muneaki Matsuo, Katsumi Higaki, Kousaku Ohno, Tetsumi Irie
Molecular Genetics and Metabolism Reports, 1, 19-30, 2014
2013
Paper#13: Applications of cryopreserved unfertilized mouse oocytes for in vitro fertilization
Naomi Nakagata,
Toru Takeo, Kiyoko Fukumoto, Tomoko Kondo, Yukie Haruguchi, Yumi Takeshita, Yuko Nakamuta, Hiroko Matsunaga, Shuuji Tsuchiyama, Yuta Ishizuka, Kimi Araki
Cryobiology, 67(2), 188-192, 2013
Paper#12: The influence of fertility on in vitro matured C57BL/6 mouse oocytes by addition of reduced glutathione to fertilization medium
Yuta Ishizuka, Manami Nishimura, Kazuya Matsumoto, Minoru Miyashita,
Toru Takeo, Naomi Nakagata, Yoshihiko Hosoi, Masayuki Anzai
Theriogenology, 80(5), 421-426, 2013
2012
Paper#11: Establishment of a transport system for mouse epididymal sperm at refrigerated temperatures
Toru Takeo, Aki Tsutsumi, Taichi Omaru, Kiyoko Fukumoto, Yukie Haruguchi, Tomoko Kondo, Yuko Nakamuta, Yumi Takeshita, Hiroko Matsunaga, Shuuji Tsuchiyama, Kazuhito Sakoh, Satohiro Nakao, Hidetaka Yoshimoto, Norihiko Shimizu, Naomi Nakagata
Cryobiology, 65(3), 163-168, 2012
2011
Paper#10: Akt1-Mediated Skeletal Muscle Growth Attenuates Cardiac Dysfunction and Remodeling after Experimental Myocardial Infarction
Araki S, Izumiya Y, Hanatani S, Rokutanda T, Usuku H, Akasaki Y,
Takeo T, Nakagata N, Walsh K, Ogawa H
Circulation. Heart failure, 5, 116-125, 2011
2010
Paper#6: Short-term storage and transport at cold temperatures of 2-cell mouse embryos produced by cryopreserved sperm
Toru Takeo, Kondo T, Haruguchi Y, Fukumoto K, Nakagawa Y, Takeshita Y, Nakamuta Y, Tsuchiyama S, Shimizu N, Hasegawa T, Goto M, Miyachi H, Anzai M, Fujikawa R, Nomaru K, Kaneko T, Itagaki Y, Nakagata N
Journal of the American Association for Laboratory Animal Science, 49, 415-419, 2010
2004-2009
Paper#4: Birth of mice from vitrified/warmed 2-cell embryos transported at a cold temperature
Takeo T, Kaneko T, Haruguchi Y, Fukumoto K, Machida H, Koga M, Nakagawa Y, Takeshita Y, Matsuguma T, Tsuchiyama S, Shimizu N, Hasegawa T, Goto M, Miyachi H, Anzai M, Nakatsukasa E, Nomaru K, Nakagata N
Cryobiology, 58(2), 196-202, 2009
Paper#3: Methyl-beta-cyclodextrin improves fertilizing ability of C57BL/6 mouse sperm after freezing and thawing by facilitating cholesterol efflux from the cells
Takeo T, Hoshii T, Kondo Y, Toyodome H, Arima H, Yamamura K, Irie T, Nakagata N
Biology of Reproduction, 78(3), 546-551, 2008
Acknowledgement