資源開発分野Division of Reproductive Engineer

Publication List

Original list is here.

2017.03.09

Paper #72: Yoshimoto H, Takeo T, Irie T, Nakagata N.
Fertility of cold-stored mouse sperm is recovered by promoting acrosome reaction and hyperactivation after cholesterol efflux by methyl-beta-cyclodextrin
Biol Reprod, 96 (2), 446-455, 2017

Paper #71: Nakagawa Y, Sakuma T, Nishimichi N, Yokosaki Y, Yanaka N, Takeo T, Nakagata N, Yamamoto T.
Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single-amino-acid-substituted, and floxed mice
Biology Open, 2016, 5(8): 1142-8. : doi: 10.1242/bio.019349

Paper #70: Takeo T and Nakagata N
Immunotherapy using inhibin antiserum enhanced the efficacy of equine chorionic gonadotropin on superovulation in major inbred and outbred mice strains
Theriogenology, 2016, 86(5): 1341-6.

Paper #69: Horikoshi Y, Takeo T and Nakagata N
N-acetyl cysteine prolonged the developmental ability of mouse two-cell embryos against oxidative stress at refrigerated temperatures
Cryobiology, 2016, 72: 198-204.

Paper #68: Takeo T and Nakagata N
El método CARD se consolida como el mejor protocolo de tecnología de la reproducción de ratón
Animales De Laboratorio, 65, 17-22, 2015.

Paper #67: Takeo T and Nakagata N
Superovulation Using the Combined Administration of Inhibin Antiserum and Equine Chorionic Gonadotropin Increases the Number of Ovulated Oocytes in C57BL/6 Female Mice
PLoS One, DOI: 10.1371/journal.pone.0128330, 2015

Paper #66: Takeo T, Horikoshi Y, Nakao S, Sakoh K, Ishizuka Y, Tsutsumi A, Fukumoto K, Kondo T, Haruguchi Y, Takeshita Y, Nakamuta Y, Tsuchiyama S, Nakagata N
Cysteine Analogs with a Free Thiol Group Promote Fertilization by Reducing Disulfide Bonds in the Zona Pellucida of Mice
Biol Reprod, 92, 1-7, 2015

Paper #65: Nakagawa Y, Sakuma T, Sakamoto T, Ohmuraya M, Nakagata N, Yamamoto T.
Production of knockout mice by DNA microinjection of various CRISPR/Cas9 vectors into freeze-thawed fertilized oocytes.
BMC Biotechnol. 2015.

Paper #64: Takeo T, Fukumoto K, Kondo T, Haruguchi Y, Takeshita Y, Nakamuta Y, Tsuchiyama S, Yoshimoto H, Shimizu N, Li MW, Kinchen K, Vallelunga J, Kent Lloyd KC, Nakagata N.
Investigations of motility and fertilization potential in thawed cryopreserved mouse sperm from cold-stored epididymides.
Cryobiology. 68(1):12-7, 2014

Paper #63: Nakagata N, Takeo T, Fukumoto K, Haruguchi Y, Kondo T, Takeshita Y, Nakamuta Y, Umeno T, Tsuchiyama S.
Rescue in vitro fertilization method for legacy stock of frozen mouse sperm.
J Reprod Dev. 24;60(2):168-71, 2014

Paper #62: Guan M, Bogani D, Marschall S, Raspa M, Takeo T, Nakagata N, Taft R, Fray M
Contemporary Techniques for Freezing Mouse Spermatozoa
Current Protocol in Mouse Biology, 4, 85-104, 2014

Paper #61: Guan M, Bogani D, Marschall S, Raspa M, Takeo T, Nakagata N, Fray M.
In Vitro Fertilization in Mice Using the MBCD-GSH Protocol.
Current Protocols in Mouse Biology, 2014

Paper #60: Kenyon J, Guan M, Bogani D, Marschall S, Raspa M, Pickard A, Takeo T, Nakagata N, Fray M.
Transporting Mouse Embryos and Germplasm as Frozen or Unfrozen Materials.
Current Protocols in Mouse Biology, 2014

Paper #59: Guan M, Bogani D, Marschall S, Raspa M, Takeo T, Nakagata N, Fray M.
Conservation of mouse models through embryo freezing.
​Current Protocol in Mouse Biology. 11;4(4):205-27. 2014

Paper #58: Ishizuka Y, Takeo T, Nakao S, Yoshimoto H, Hirose Y, Sakai Y, Horikoshi Y, Takeuji S, Tsuchiyama S, Nakagata N.
Prolonged exposure to hyaluronidase decreases the fertilization and development rates of fresh and cryopreserved mouse oocytes.
Journal of Reproduction and Development, 2014

Paper #57: Nakagawa Y, Sakuma T, Nakagata N, Yamasaki S, Takeda N, Ohmuraya M, Yamamoto T.
Application of Oocyte Cryopreservation Technology in TALEN-Mediated Mouse Genome Editing.
Exp Anim. 63(3):349-55, 2014 .

Paper #56: Watanabe H, Takeo T, Tojo H, Sakoh K, Berger T, Nakagata N, Mak TW, Kondoh G.
Lipocalin 2 binds to membrane phosphatidylethanolamine to induce lipid raft movement in a PKA-dependent manner and modulates sperm maturation.
Development. 141(10):2157-64, 2014

Paper #55: Ishizuka Y, Nishimura M, Matsumoto K, Miyashita M, Takeo T, Nakagata N, Hosoi Y, Anzai M.
The influence of reduced glutathione in fertilization medium on the fertility of in vitro-matured C57BL/6 mouse oocytes.
Theriogenology. 80(5):421-6, 2013

Paper #54: Nakagata N, Takeo T, Fukumoto K, Kondo T, Haruguchi Y, Takeshita Y, Nakamuta Y, Matsunaga H, Tsuchiyama S, Ishizuka Y, Araki K.
Applications of cryopreserved unfertilized mouse oocytes for in vitro fertilization.
Cryobiology 67(2):188-92. 2013

Paper #53: Donahue LR, Hrabe de Angelis M, Hagn M, Franklin C, Lloyd KC, Magnuson T, McKerlie C, Nakagata N, Obata Y, Read S, Wurst W, Horlein A, Davisson MT.
Centralized mouse repositories.
Mamm Genome. 2012 Oct;23(9-10):559-71.

Paper #52: Takeo T, Tsutsumi A, Omaru T, Fukumoto K, Haruguchi Y, Kondo T, Nakamuta Y, Takeshita Y, Matsunaga H, Tsuchiyama S, Sakoh K, Nakao S, Yoshimoto H, Shimizu N, Nakagata N.
Establishment of a transport system for mouse epididymal sperm at refrigerated temperatures.
Cryobiology. 2012 Dec;65(3):163-8.

Paper #51: 西村愛美、中牟田裕子、福本紀代子、近藤朋子、春口幸恵、竹下由美、土山修治、石川裕子、石束祐太、細井美彦、三谷 匡、竹尾 透、中潟直己、安斉政幸
マウス体外成熟由来2細胞期胚を用いた冷蔵輸送・保存方法の検討
Mem. Faculty B. O. S. T. Kinki University 29 33-42 2012年3月

Paper #50: Takeo, T. and Nakagata, N.
Reduced glutathione enhances fertility of frozen/thawed C57BL/6 mouse sperm after exposure to methyl-beta-cyclodextrin.
Biol Reprod. 85(5):1066-72. 2011.

Paper #49: Nishimura M, Fukumoto K, Nakamuta Y, Hosoi Y, Takeo T, Nakagata N, Anzai M.
Transport of 2-cell embryos produced by intracytoplasmic sperm injection (ICSI) at cold temperatures (4oC).
Mem. Faculty B. O. S. T. Kinki University, 28, 109-116 (2011)

Paper #48: Nakagata, N.
Cryopreservation of mouse spermatozoa and in vitro fertilization.
Methods Mol Biol. 693:57-73. 2011.

Paper #47: Nakagata, N.
Mouse Bank at CARD Kumamoto University, Japan.
IBC2010. 2:1-4.2010.

Paper #46: Takeo, T and Nakagata, N.
Mouse sperm cryopreservation and effective embryo production using cryopreserved C57BL/6 mouse sperm.
Journal of Mammalian Ova Research. 27:70-78.Oct 2010.

Paper #45: Takeo T, Kondo T, Haruguchi Y, Fukumoto K, Nakagawa Y, Takeshita Y, Nakamuta Y, Tsuchiyama S, Shimizu N, Hasegawa T, Goto M, Miyachi H, Anzai M, Fujikawa R, Nomaru K, Kaneko T, Itagaki Y, Nakagata N.
Short-term storage and transport at cold temperatures of 2-cell mouse embryos produced by cryopreserved sperm.
J Am Assoc Lab Anim Sci. 49(4):415-9. Jul 2010.

Paper #44: Takeo T and Nakagata N.
Combination medium of cryoprotective agents containing L-glutamine and methyl-{beta}-cyclodextrin in a preincubation medium yields a high fertilization rate for cryopreserved C57BL/6J mouse sperm.
Lab Anim. 44(2):132-7.Apr 2010.

Paper #43: Nakagata N, and Yamamura K.
Current activities of CARD as an international core center for mouse resources.
Exp Anim. 58(4):343-50.2009.

Paper #42: Kaneko T, Fukumoto K, Haruguchi Y, Kondo T, Machida H, Koga M, Nakagawa Y, Tsuchiyama S, Saiki K, Noshiba S, and Nakagata N.
Fertilization of C57BL/6 mouse sperm collected from cauda epididymides after preservation or transportation at 4 degrees C using laser-microdissected oocytes.
Cryobiology. 59(1):59-62 2009.

Paper #41: Kaneko T, Kimura S, and Nakagata N.
Importance of primary culture conditions for the development of rat ICSI embryos and long-term preservation of freeze-dried sperm.
Cryobiology. 58(3):293-7 2009.

Paper #40: Takeo T, Kaneko T, Haruguchi Y, Fukumoto K, Machida H, Koga M, Nakagawa Y, Takeshita Y, Matsuguma T, Tsuchiyama S, Shimizu N, Hasegawa T, Goto M, Miyachi H, Anzai M, Nakatsukasa E, Nomaru K, and Nakagata N.
Birth of mice from vitrified/warmed 2-cell embryos transported at a cold temperature.
Cryobiology. 58(2):196-202 2009.

Paper #39: Takeo, T., Hoshii, T., Kondo, Y., Toyodome, H., Arima, H., Yamamura, KI., Irie, T. and Nakagata, N.
Methyl-Beta-Cyclodextrin Improves Fertilizing Ability of C57BL/6 Mouse Sperm after Freezing and Thawing by Facilitating Cholesterol Efflux from the Cells.
Biol Reprod. 78(3):546-51. 2008.

Paper #38: Kaneko, T., Kimura, S. and Nakagata, N.
Offspring derived from oocytes injected with rat sperm, frozen or freeze-dried without cryoprotection.
Theriogenology. 68(7):1017-1021, 2007.

Paper #37: Nakagata, N.
Mouse bank.
Nippon Yakurigaku Zasshi. 129(5):343-348, 2007.

Paper #36: Kaneko T and Nakagata N.
Improvement in the long-term stability of freeze-dried mouse spermatozoa by adding of a chelating agent.
Cryobiology, 53(2):279-82.2006.

Paper #35: Kaneko T, Yanagi M, Nakashima T, Nakagata N.
The improvement in fertility of cryopreserved mouse spermatozoa showing low fertility using laser-microdissected oocytes.
Reprod. Med. Biol., 5(4), 249-254.2006.

Paper #34: Anzai M, Nishiwaki M, Yanagi M, Nakashima T, Kaneko T, Taguchi Y, Tokoro M,Shin SW, Mitani T, Kato H, Matsumoto K, Nakagata N, Iritani A.
Application of Laser-assisted Zona Drilling to In Vitro Fertilization of Cryopreserved Mouse Oocytes with Spermatozoa from a Subfertile Transgenic Mouse.
J. Reprod. Dev., 52(5):601-606.2006.

Paper #33: Kaneko T, Yamamura A, Ide Y, Ogi M, Yanagita T, Nakagata N.
Long-term cryopreservation of mouse sperm.
Theriogenology, 66(5):1098-101.2006.

Paper #32: Kaneko T, and Nakagata,N.
Relation between Storage Temperature and Fertilizing Ability of Freeze-Dried Mouse Spermatozoa.
Comp Med., 55(2), 140-144. 2005.

Paper #31: Sakamoto,W., Kaneko,T., Nakagata,N.
Use of frozen-thawed oocytes for efficient production of normal offspring from cryopreserved mouse spermatozoa showing low fertility.
Comp Med., 55(2), 136-139.2005.

Paper #30: Nishizono,H., Shioda,M., Takeo,T., Irie,T., Nakagata,N.
Decrease of fertilizing ability of mouse spermatozoa after freezing and thawing is related to cellular injury.
Biol.Reprod., 71(3), 973-978, 2004.

Paper #29: Nakatsukasa, E., Kashiwazaki, N., Takizawa, A., Shino, M., Kitada, K., Serikawa, T., Hakamata, Y., Kobayashi, E., Takahashi, R., Ueda, M., Nakashima,T., and Nakagata,N.
Cryopreservation of Spermatozoa from Closed Colonies, and Inbred, Spontaneous Mutant, and Transgenic Strains of Rat.
Comp. Med. 56: 511-513. 2003.

Paper #28: Kamimura, E., Nakashima, T., Ogawa, M., Ohwada, K., Nakagata,N.
Study of low-temperature (4 degrees C) transport of mouse two-cell embryos enclosed in oviducts.
Comp. Med. 53: 393-396. 2003.

Paper #27: Okamoto, M., Nakagata,N. and Toyoda,Y.
Cryopreservation and transport of mouse spermatozoa at -79 degrees C.
Exp. Anim. 50: 83-86. 2001.

Paper #26: Nakagata,N.
Mouse Spermatozoa Cryopreservation.
J. Mamm. Ova Res. 17: 1-8. 2000.

Paper #25: Nakagata,N.
Cryopreservation of mouse spermatozoa.
Mamm. Genome. 11: 572-576. 2000.

Paper #24: Nakagata N.
Cryopreservation of mouse embryo and gametes and their application.
Exp Anim. 47(3):suppl 131-8. 1998. Review. Japanese.

Paper #23: Nakao K, Nakagata N, Katsuki M.
Production of chimeric mice from cryopreserved blastocysts.
Exp Anim. 47(3):167-71. 1998.

Paper #22: Nakagata N, Okamoto M, Ueda O, Suzuki H.
Positive effect of partial zona-pellucida dissection on the in vitro fertilizing capacity of cryopreserved C57BL/6J transgenic mouse spermatozoa of low motility.
Biol Reprod. 57(5): 1050-5. 1997.

Paper #21: Nakao K, Nakagata N, Katsuki M.
Simple and efficient vitrification procedure for cryopreservation of mouse embryos.
Exp Anim. 46(3):231-4. 1997.

Paper #20: Suzuki H, Nakagata N, Anzai M, Tsuchiya K, Nakura M, Yamaguchi S, Toyoda Y.
Transport of wild mice genetic material by in vitro fertilization, cryopreservation, and embryo transfer.
Lab Anim Sci. 46(6):687-8. 1996. Review.

Paper #19: Nakagata N.
Use of cryopreservation techniques of embryos and spermatozoa for production of transgenic (Tg)mice and for maintenance of Tg mouse lines.
Lab Anim Sci. 46(2):236-8. 1996.

Paper #18: Nakagata N, Ueda S, Yamanouchi K, Okamoto M, Matsuda Y, Tsuchiya K, Nishimura M, Oda S, Koyasu K, Azuma S, Toyoda Y.
Cryopreservation of wild mouse spermatozoa.
Theriogenology. 43(3):635-43. 1995.

Paper #17: Nakagata N.
Studies on cryopreservation of embryos and gametes in mice.
Exp Anim. 44(1):1-8. 1995 . Review.

Paper #16: Matsumoto K, Anzai M, Nakagata N, Takahashi A, Takahashi Y, Miyata K.
Onset of paternal gene activation in early mouse embryos fertilized with transgenic mouse sperm.
Mol Reprod Dev. 39(2):136-40. 1994.

Paper #15: Anzai M, Nakagata N, Matsumoto K, Ishikawa T, Takahashi Y, Miyata K.
Production of transgenic mice from in vitro fertilized eggs cryopreserved by ultrarapid freezing
Jikken Dobutsu. 43(3):445-8. 1994.

Paper #14: Nakagata N.
Cryopreservation of embryos and gametes in mice.
Jikken Dobutsu. 43(1):11-8. 1994. Review.

Paper #13: Nakagata N.
Production of normal young following transfer of mouse embryos obtained by in vitro fertilization between cryopreserved gametes.
J Reprod Fertil. 99(1):77-80. 1993.

Paper #12: Anzai M, Nakagata N, Matsumoto K, Takahasi A, Takahasi Y, Miyata K.
Cryopreservation of transgenic mouse embryos by ultrarapid freezing.
Jikken Dobutsu. 42(3):467-70. 1993.

Paper #11: Nakagata N, Takeshima T.
Cryopreservation of mouse spermatozoa from inbred and F1 hybrid strains.
Jikken Dobutsu. 42(3):317-20. 1993.

Paper #10: Nakagata N.
Survival of mouse morulae and blastocysts derived from in vitro fertilization after ultra rapid freezing.
Jikken Dobutsu. 42(2):229-31. 1993.

Paper #9: Nakagata N, Matsumoto K, Anzai M, Takahashi A, Takahashi Y, Matsuzaki Y, Miyata K.
Cryopreservation of spermatozoa of a transgenic mouse.
Jikken Dobutsu. 41(4):537-40. 1992.

Paper #8: Nakagata N.
Production of normal young following insemination of frozen-thawed mouse spermatozoa into fallopian tubes of pseudopregnant females.
Jikken Dobutsu. 41(4):519-22. 1992.

Paper #7: Nakagata N.
Embryo transfer through the wall of the fallopian tube in mice.
Jikken Dobutsu. 41(3):387-8. 1992.

Paper #6: Takeshima T, Nakagata N, Ogawa S.
Cryopreservation of mouse spermatozoa.
Jikken Dobutsu. 40(4):493-7. 1991.

Paper #5: Nakagata N.
Method of dissecting of ovarian bursal membranes using a bipolar coagulator in mice and rats.
Jikken Dobutsu. 39(4):593-5. 1990.

Paper #4: Nakagata N.
Cryopreservation of unfertilized mouse oocytes from inbred strains by ultrarapid freezing.
Jikken Dobutsu. 39(2):303-5. 1990.

Paper #3: Nakagata N.
Cryopreservation of mouse strains by ultrarapid freezing].
Jikken Dobutsu. 39(2):299-301. 1990 .

Paper #2: Nakagata N.
High survival rate of unfertilized mouse oocytes after vitrification.
J Reprod Fertil. 87(2):479-83. 1989.

Paper #1: Nakagata N.
Survival of 4-cell mouse embryos derived from in vitro fertilization after ultrarapid freezing and thawing.
Jikken Dobutsu. 38(3):279-82. 1989.
Collaborations using Genetically Engineered Mice
Collaboration paper #78: Nakagawa T, Hasegawa Y, Uekawa K, Senju S, Nakagata N, Matsui K, Kim-Mitsuyama S.
Transient Mild Cerebral Ischemia Significantly Deteriorated Cognitive Impairment in a Mouse Model of Alzheimer's Disease via Angiotensin AT1 Receptor.
Am J Hypertens. In Press.

Collaboration paper #77: Omori H, Ogaki S, Sakano D, Sato M, Umeda K, Takeda N, Nakagata N, Kume S.
Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development.
FEBS Lett. 2016; 590(16): 2584-93.

Collaboration paper #76: Uekawa K, Hasegawa Y, Senju S, Nakagata N, Ma M, Nakagawa T, Koibuchi N, Kim-Mitsuyama S.
Intracerebroventricular Infusion of Angiotensin-(1-7) Ameliorates Cognitive Impairment and Memory Dysfunction in a Mouse Model of Alzheimer's Disease.
J Alzheimers Dis. 2016, 53:127-33.

Collaboration paper #75: Baba M, Toyama H, Sun L, Takubo K, Suh HC, Hasumi H, Nakamura-Ishizu A, Hasumi Y, Klarmann KD, Nakagata N, Schmidt LS, Linehan WM, Suda T, Keller JR.
Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure.
Stem Cells. 2016; 34:1068-82.

Collaboration paper #74: Kuwahara K, Yamamoto-Ibusuki M, Zhang Z, Phimsen S, Gondo N,  Yamashita H,  Takeo T, Nakagata N, Yamashita D, Fukushima Y, Yamamoto Y, Iwata H, Saya H, Kondo E, Matsuo K, Takeya M, Iwase H,
​Sakaguchi N
GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development
Cancer Science, 107: 469-77, 2016.

Collaboration paper #73: Matsumaru D, Murashima A, Fukushima J, Senda S, Matsushita S, Nakagata N, Miyajima M, Yamada G.
Systematic stereoscopic analyses for cloacal development: The origin of anorectal malformations.
Sci Rep. 10;5:13943, 2015

Collaboration paper #72: Maeda Y, Motoyama K, Higashi T, Horikoshi Y, Takeo T, Nakagata N, Kurauchi Y, Katsuki H, Ishitsuka Y,  Kondo Y, Irie T, Furuya H, Era T, Arima H
Effects of Cyclodextrins on GM1-gangliosides in Fibroblasts from GM1-gangliosidosis Patients
Journal of Pharmacy and Pharmacology, 67, 1133-1142, 2015

Collaboration paper #71: Soga M, Ishitsuka Y, Hamasaki M, Yoneda K, Furuya H, Matsuo M, Ihn H, Fusaki N, Nakamura K, Nakagata N, Endo F, Irie T, Era T.
HPGCD Outperforms HPBCD as A Potential Treatment for Niemann-Pick Disease Type C During disease Modeling with iPS Cells.
Stem Cells. 33, 2885-2886, 2015

Collaboration paper #70: Takamatsu K, Ikeda T, Haruta M, Matsumura K, Ogi Y, Nakagata N, Uchino M, Ando Y, Nishimura Y, Senju S.
Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing Neprilysin-2.
Stem Cell Res. 13(3PA):442-453, 2014

Collaboration paper #69: Suzuki K, Numata T, Suzuki H, Raga DD, Ipulan LA, Yokoyama C, Matsushita S, Hamada M, Nakagata N, Nishinakamura R, Kume S, Takahashi S, Yamada G.
Sexually dimorphic expression of Mafb regulates masculinization of the embryonic urethral formation.
Proc Natl Acad Sci U S A. 111(46):16407-12, 2014

Collaboration paper #68: Tanaka Y, Ishitsuka Y, Yamada Y, Kondo Y, Takeo T, Nakagata N, Higashi T, Motoyama K, Arima H, Matsuo M, Higaki K, Ohno K, Irie T.
Influence of Npc1 genotype on the toxicity of hydroxypropyl-β-cyclodextrin, a potentially therapeutic agent, in Niemann-Pick Type C disease models.
Molecular Genetics and Metabolism Reports 1 19-30, 2014

Collaboration paper #67: Ipulan LA, Suzuki K, Sakamoto Y, Murashima A, Imai Y, Omori A, Nakagata N, Nishinakamura R, Valasek P, Yamada G.
Nonmyocytic androgen receptor regulates the sexually dimorphic development of the embryonic bulbocavernosus muscle.
Endocrinology. 155(7):2467-79, 2014

Collaboration paper #66: Omori A, Miyagawa S, Ogino Y, Harada M, Ishii K, Sugimura Y, Ogino H, Nakagata N, Yamada G.
Essential roles of epithelial bone morphogenetic protein signaling during prostatic development.
Endocrinology. 155(7):2534-44, 2014

Collaboration paper #65: Miyagawa S, Harada M, Matsumaru D, Tanaka K, Inoue C, Nakahara C, Haraguchi R, Matsushita S, Suzuki K, Nakagata N, Ng RC, Akita K, Lui VC, Yamada G.
Disruption of the temporally regulated cloaca endodermal β-catenin signaling causes anorectal malformations.
Cell Death Differ. 21(6):990-7, 2014

Collaboration paper #64: Araki M, Nakahara M, Muta M, Itou M, Yanai C, Yamazoe F, Miyake M, Morita A, Araki M, Okamoto Y, Nakagata N, Yoshinobu K, Yamamura KI, Araki K.
Database for exchangeable gene trap clones: Pathway and gene ontology analysis of exchangeable gene trap clone mouse lines.
Dev Growth Differ. 56 (2):161-174, 2014

Collaboration paper #63: Murashima A, Akita H, Okazawa M, Kishigami S, Nakagata N, Nishinakamura R, Yamada G
Midline-derived Shh regulates mesonephric tubule formation through the paraxial mesoderm.
Dev Biol. 386(1):216-26, 2014

Collaboration paper #62: Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S.
VMAT2 identified as a regulator of late-stage β-cell differentiation.
Nat Chem Biol. 10(2):141-8, 2014

Collaboration paper #61: Matsumaru D, Haraguchi R, Moon AM, Satoh Y, Nakagata N, Yamamura K, Takahashi N, Kitazawa S, Yamada G. Eur J Hum Genet.
Genetic analysis of the role of Alx4 in the coordination of lower body and external genitalia formation.
European Journal of Human Genetics, 22(3):350-7, 2014

Collaboration paper #60: Nakahara M, Tateyama H, Araki M, Nakagata N, Yamamura K, Araki K.
Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice.
Mamm Genome. 24(5-6):228-39. 2013

Collaboration paper #59: Mazahery AR, Suzuki K, Nagafuchi A, Miyajima M, Nakagata N, Orvis GD, Behringer RR, Yamada G.
Functional analysis of ectodermal β-catenin during external genitalia formation.
Congenit Anom (Kyoto) 53(1):34-41, 2013

Collaboration paper #58: Semba K, Araki K, Matsumoto K, Suda H, Ando T, Sei A, Mizuta H, Takagi K, Nakahara M, Muta M, Yamada G, Nakagata N, Iida A, Ikegawa S, Nakamura Y, Araki M, Abe K,
Yamamura K.
Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice.
PLoS Genet, 9(2): 2013

Collaboration paper #57: Araki S, Izumiya Y, Hanatani S, Rokutanda T, Usuku H, Akasaki Y, Takeo T, Nakagata N, Walsh K, Ogawa H.
Akt1-mediated skeletal muscle growth attenuates cardiac dysfunction and remodeling after experimental myocardial infarction.
Circ Heart Fail. 2012 Jan;5(1):116-25. Epub 2011 Dec 1.

Collaboration paper #56: Hojo H, Ohba S, Taniguchi K, Shirai M, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Mishina Y, Yamada M, Konno T, Takato T, Kawaguchi H, Kambara H, Chung UI.
Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium.
J Biol Chem. 288(14):9924-9932. 2013

Collaboration paper #55: Hojo H, Ohba S, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, Chung UI.
Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification.
J Biol Chem. 2012 May 18;287(21):17860-9. Epub 2012 Apr 9.

Collaboration paper #54: Hayashi H, Eguchi Y, Fukuchi-Nakaishi Y, Takeya M, Nakagata N, Tanaka K, Vance JE, Tanihara H.
A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma.
J Biol Chem. 2012 Jul 20;287(30):25395-406. doi: 10.1074/jbc.M112.370130. Epub 2012 Jun 6.

Collaboration paper #53: Haraguchi R, Matsumaru D, Nakagata N, Miyagawa S, Suzuki K, Kitazawa S, Yamada G.
The hedgehog signal induced modulation of bone morphogenetic protein signaling: an essential signaling relay for urinary tract morphogenesis.
PLoS One. 2012;7(7):e42245. Epub 2012 Jul 30.

Collaboration paper #52: M, Suzuki K, Hirasawa A, Ohkawa Y, Suyama M, Maruyama T, Aoki D, Ogino Y, Miyagawa S, Terabayashi T, Tomooka Y, Nakagata N, Yamada G.
β-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation.
Villacorte Oncogene. 2012 Sep 3. doi: 10.1038/onc.2012.376.

Collaboration paper #51: Suzuki K, Adachi Y, Numata T, Nakada S, Yanagita M, Nakagata N, Evans SM, Graf D, Economides A, Haraguchi R, Moon AM, Yamada G.
Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia.
PLoS One. 2012;7(9):e43453. doi: 10.1371/journal.pone.0043453. Epub 2012 Sep 17.

Collaboration paper #50: Araki, S., Izumiya, Y., Hanatani, S., Rokutanda, T., Usuku, H., Akasaki, Y., Takeo, T., Nakagata, N., Walsh, K. and Ogawa H.
Akt1-mediated skeletal muscle growth attenuates cardiac dysfunction and remodeling after experimental myocardial infarction.
Circ Heart Fail. 5(1):116-25. 2011.

Collaboration paper #49: Liu, L., Suzuki, K., Nakagata, N., Mihara, K., Matsumaru, D., Ogino, Y., Yashiro, K., Hamada, H., Liu, Z., Evans, SM., Mendelsohn, C. and Yamada, G.
Retinoic acid signaling regulates Sonic hedgehog and bone morphogenetic protein signalings during genital tubercle development.
Birth Defects Res B Dev Reprod Toxicol. doi:10.1002/bdrb.20344. 2011.

Collaboration paper #48: Kawakami, M,, Umedam M,, Nakagata, N., Takeo,T. and Yamamura, K.
Novel migrating mouse neural crest cell assay system utilizing P0-Cre/EGFP fluorescent time-lapse imaging.
BMC Dev Biol. 11:68. 2011.

Collaboration paper #47: Harada, N., Zhao, J., Okajima, K., Kurihara, H. and Nakagata, N.
Retraction: Stimulation of FcγRI on primary sensory neurons increases insulin-like growth factor-I production, thereby reducing reperfusion-induced renal injury in mice.
J Immunol.187(6):3448. 2011

Collaboration paper #46: Omori, A., Harada, M., Ohta, S., Villacorte, M., Sugimura, Y., Shiraishi, T., Suzuki, K., Nakagata, N., Ito, T. and Yamada, G.
Epithelial Bmp (Bone morphogenetic protein) signaling for bulbourethral gland development: a mouse model for congenital cystic dilation.
Congenit Anom (Kyoto). 2011 Sep;51(3):102-9. doi: 10.1111/j.1741-4520.2011.00318.x. 2011.

Collaboration paper #45: Harada, N., Zhao, J., Kurihara, H., Nakagata, N. and Okajima, K.
Desalted deep-sea water improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus.
Transl Res. 2011 Aug;158(2):106-17. Epub 2011 Mar 21. Erratum in: Transl Res. 2011 Dec;158(6):387.

Collaboration paper #44: Miyagawa, S., Matsumaru, D., Murashima, A., Omori, A., Satoh, Y., Haraguchi, R., Motoyama, J., Iguchi, T., Nakagata, N., Hui, CC. and Yamada, G.
The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitalia.
Endocrinology. 152(7):2894-903. 2011.

Collaboration paper #43: Kawakami, M., Yoshimoto, T., Nakagata, N., Yamamura, K. and Siesjo, BK.
Effects of cyclosporin A administration on gene expression in rat brain.
Brain Inj. 25(6):614-23. 2011.

Collaboration paper #42: Harada, N., Zhao, J., Kurihara, H., Nakagata, N. and Okajima, K.
Resveratrol improves cognitive function in mice by increasing production of insulin-like growth factor-I in the hippocampus.
J Nutr Biochem. 22(12):1150-9. 2011.

Collaboration paper #41: Matsumaru, D., Haraguchi, R., Miyagawa, S., Motoyama, J., Nakagata, N., Meijlink, F. and Yamada, G.
Genetic analysis of Hedgehog signaling in ventral body wall development and the onset of omphalocele formation.
PLoS One. 6(1):e16260. 2011.

Collaboration paper #40: Matsumaru D, Haraguchi R, Miyagawa S, Motoyama J, Nakagata N, Meijlink F, Yamada G.
Genetic analysis of Hedgehog signaling in ventral body wall development and the onset of omphalocele formation.
PLoS One.; 6(1): e16260. Jan 20 2011.

Collaboration paper #39: Ando T, Semba K, Suda H, Sei A, Mizuta H, Araki M, Abe K, Imai K, Nakagata N, Araki K, Yamamura K.
The floor plate is sufficient for development of the sclerotome and spine without the notochord.
Mech Dev. 128(1-2):129-40. Jan-Feb 2011.

Collaboration paper #38: Sato Y, Takata H, Kobayashi N, Nagata S, Nakagata N, Ueno T, Takiguchi M.
Failure of effector function of human CD8+ T Cells in NOD/SCID/JAK3/
immunodeficient mice transplanted with human CD34+ hematopoietic stem cells.
PLoS One.;5(10). pii: e13109. Oct 1 2010.

Collaboration paper #37: Namba T, Hoshino T, Suemasu S, Takarada-Iemata M, Hori O, Nakagata N, Yanaka A, Mizushima T.
Suppression of expression of endoplasmic reticulum chaperones by Helicobacter pylori and its role in exacerbation of non-steroidal anti-inflammatory drug-induced gastric lesions.
J Biol Chem. ;285(48):37302-13.Nov 26 2010.

Collaboration paper #36: Ramadan A, Nobuhisa I, Yamasaki S, Nakagata N, Taga T.
Cells with hematopoietic activity in the mouse placenta reside in side population.
Genes Cells.;15(9):983-94. Sep 1 2010.

Collaboration paper #35: Uchiyama Y, Sakaguchi M, Terabayashi T, Inenaga T, Inoue S, Kobayashi C, Oshima N, Kiyonari H, Nakagata N, Sato Y, Sekiguchi K, Miki H, Araki E, Fujimura S, Tanaka SS, Nishinakamura R.
Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme.
Proc Natl Acad Sci U S A. ;107(20):9240-5. May 18 2010.

Collaboration paper #34: Wang J, Ohmuraya M, Suyama K, Hirota M, Ozaki N, Baba H, Nakagata N, Araki K, Yamamura K.
Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression.
Lab Invest; 90(5):654-64. May 2010.

Collaboration paper #33: Villacorte M, Suzuki K, Hayashi K, de Sousa Lopes SC, Haraguchi R, Taketo MM, Nakagata N, Yamada G.
Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation.
Biochem Biophys Res Commun.;391(4):1653-7. Jan 22 2010.

Collaboration paper #32: Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, Shimabukuro M, Sakaguchi K, Ito T, Nakagata N, Yamada T, Katagiri H, Kasuga M, Ando Y, Ogawa H, Mochizuki N, Itoh H, Suda T, Oike Y.
Cell Metab.;10(3):178-88. Sep 2009.

Collaboration paper #31: Yamamoto E, Kataoka K, Dong YF, Nakamura T, Fukuda M, Tokutomi Y, Matsuba S, Nako H, Nakagata N, Kaneko T, Ogawa H, and Kim-Mitsuyama S.
Aliskiren Enhances the Protective Effects of Valsartan Against Cardiovascular and Renal Injury in Endothelial Nitric Oxide Synthase-Deficient Mice.
Hypertension. 2009.

Collaboration paper #30: Nitta Y, Shigeyoshi Y, Nakagata N, Kaneko T, Nitta K, Harada T, Ishizaki F, and Townsend J.
Kinetics of blood glucose in mice carrying hemizygous Pax6.
Exp Anim. 58(2):105-12 2009.

Collaboration paper #29: Miyagawa S, Satoh Y, Haraguchi R, Suzuki K, Iguchi T, Taketo MM, Nakagata N, Matsumoto T, Takeyama K, Kato S, and Yamada G.
Genetic interactions of the androgen and Wnt/{beta}-catenin pathways for the masculinization of external genitalia.
Mol Endocrinol. 23(6):871-80 2009.

Collaboration paper #28: Suzuki K, Yamaguchi Y, Villacorte M, Mihara K, Akiyama M, Shimizu H, Taketo MM, Nakagata N, Tsukiyama T, Yamaguchi TP, Birchmeier W, Kato S, and Yamada G.
Embryonic hair follicle fate change by augmented beta-catenin through Shh and Bmp signaling.
Development. 136(3):367-72 2009.

Collaboration paper #27: Araki K, Takeda N, Yoshiki A, Obata Y, Nakagata N, Shiroishi T, Moriwaki K, and Yamamura K.
Establishment of germline-competent embryonic stem cell lines from the MSM/Ms strain.
Mamm Genome. 20(1):14-20 2009.

Collaboration paper #26: Zhang D, Shimizu T, Araki N, Hirota T, Yoshie M, Ogawa K, Nakagata N, Takeya M, and Saya H.
Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.
Oncogene. 27(31):4305-14 2008.

Collaboration paper #25: Nishida H, Miyagawa S, Vieux-Rochas M, Morini M, Ogino Y, Suzuki K, Nakagata N, Choi HS, Levi G, and Yamada G.
Positive regulation of steroidogenic acute regulatory protein gene expression through the interaction between Dlx and GATA-4 for testicular steroidogenesis.
Endocrinology. 149(5):2090-7 2008.

Collaboration paper #24: Yoshida, M., Kuwahara, K., Shimasaki, T., Nakagata, N., Matsuoka, M. and Sakaguchi, N.
GANP suppresses DNA recombination, measured by direct-repeat beta-galactosidase gene construct, but does not suppress the type of recombination applying to immunoglobulin genes in mammalian cells.
Genes Cells. 12(10):1205-1213, 2007.

Collaboration paper #23: Yokomine, K., Nakatsura, T., Senju, S., Nakagata, N., Minohara, M., Kira, J., Motomura, Y., Kubo, T., Sasaki, Y. and Nishimura, Y.
Regression of intestinal adenomas by vaccination with heat shock protein 105-pulsed bone marrow-derived dendritic cells in Apc(Min/+) mice.
Cancer Sci. 98(12):1930-1935, 2007.

Collaboration paper #22: Suzuki, K., Haraguchi, R., Ogata, T., Barbieri, O., Alegria, O., Vieux-Rochas, M., Nakagata, N., Ito, M., Mills, AA., Kurita, T., Levi, G. and Yamada, G.
Abnormal urethra formation in mouse models of Split-hand/split-foot malformation type 1 and type 4.
Eur J Hum Genet. 16(1):36-44, 2008.

Collaboration paper #21: Nitta, Y., Yoshida, K., Nakagata, N., Nitta, K., Harada, T. and Ishizaki, F.
Intestinal tumorigenicity of mice carrying hemizygous Pax6, Pax6(Sey-4H).
Exp Anim. 56(4):289-294, 2007.

Collaboration paper #20: Yamaguchi, Y., Nagase, T., Tomita, T., Nakamura, K., Fukuhara, S., Amano, T., Yamamoto, H., Ide, Y., Suzuki, M., Teramoto, S., Asano, T., Kangawa, K., Nakagata, N., Ouchi, Y. and Kurihara, H.
Beta-defensin overexpression induces progressive muscle degeneration in mice.
Am J Physiol Cell Physiol. 292(6):C2141-2209, 2007.

Collaboration paper #19: Hoshii,T., Takeo,T., Nakagata,N., Takeya,M., Araki,K.and Yamamura,K.:
LGR4 Regulates the Postnatal Development and Integrity of Male Reproductive Tracts in Mice.
Biol. Reprod., 76(2), 303-313, 2007.

Collaboration paper #18: Haraguchi,R., Motoyama,J., Sasaki,H., Satoh,Y., Miyagawa,S., Nakagata,N., Moon,A.and Yamada,G.:
Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling.
Development, 134(3), 525-533,2007.

Collaboration paper #17: Nobuhisa,I., Ohtsu,N., Okada,S., Nakagata,N. and Taga,T.:
Identification of a population of cells with hematopoietic stem cell properties in mouse aorta-gonad-mesonephros cultures.
Exp. Cell Res., 313(5), 965-974,2007.

Collaboration paper #16: Yamada,G., Suzuki,K., Haraguchi,R., Miyagawa,S., Satoh,Y., Kamimura,M., Nakagata,N., Kataoka, H., Kuroiwa,A.and Chen,Y.:
Molecular genetic cascades for external genitalia formation: an emerging organogenesis program.
Dev. Dyn., 235(7), 1738-1752, 2006.

Collaboration paper #15: Yoshimoto,N., Shimoda,K., Mori,Y., Honda,R., Okamura,H., Ide,Y., Nakashima,T., Nakagata,N.,Torii,R., Yoshikawa,Y.and Hayasaka,I.
Ovarian follicular development stimulated by leuprorelin acetate plus human menopausal gonadotropin in chimpanzees.
J.Med.Primatol., 34(2),73-85.2005.

Collaboration paper #14: Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y., Imaizumi,T., Saito,F.,Muta,M., Soejima,Y., Utoh,A., Nakagata,N., Araki,M., Yamamura, K. and Araki,K.:
Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta
geo cassette.
Dev.Growth.Differ., 47(3),163-172, 2005.

Collaboration paper #13: Oike,Y., Akao,M., Yasunaga,K., Yamauchi,T., Morisada,T., Ito,Y., Urano, T., Kimura,Y., Kubota,Y., Maekawa,H., Miyamoto,T., Miyata,K., Matsumoto, S., Sakai,J., Nakagata,N., Takeya,M.,Koseki,H., Ogawa,Y., Kadowaki,T. and Suda,T.
Angiopoietin-related growth factor antagonizes obesity and insulin resistance.
Nat.Med., 11(4),400-408, Epub 2005.

Collaboration paper #12: Kanato,K., Hosen,N., Yanagihara,M., Nakagata,N., Shirakata,T., Nakazawa,T.,Nishida,S., Tsuboi,A,, Kawakami,M., Masuda,T., Oka,Y., Oji,Y., Ijpenberg,A.,Hastie,ND., Sugiyama,H.
The Wilms' tumor gene WT1 is a common marker of progenitor cells in fetal liver.
Biochem.Biophys.Res.Commun., 28;326(4),836-843, 2005.

Collaboration paper #11: Ito,K., Hirao,A., Arai,F., Matsuoka,S., Takubo,K., Hamaguchi,I., Nomiyama,K.,Hosokawa,K., Sakurada,K., Nakagata,N., Ikeda,Y., Mak,TW., Suda,T.
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells.
Nature, 431(7011), 997-1002, 2004.

Collaboration paper #10: Nitta,Y., Yoshida,K., Satoh,K., Senba,K., Nakagata,N., Peters,J., Cattanach,BM.
Spontaneous and Radiation-induced Leukemogenesis of the Mouse Small Eye Mutant,
Pax6(Sey3H).
J.Radiat.Res., 45(2), 245-251, 2004.

Collaboration paper #9: Suzuki,K., Yoshimoto,N., Shimoda,K., Sakamoto,W., Ide,Y., Kaneko,T.,Nakashima T, Hayasaka I, Nakagata,N.
Cytoplasmic dysmorphisms in metaphase II chimpanzee oocytes.
Reprod.Biomed.Online., 9(1), 54-58, 2004.

Collaboration paper #8: Nitta,Y., Yoshida,K., Nakagata,N., Harada,T., Ishizaki,F., Nitta K.,Torii,M.:
Effects of a hemizygous deletion of mouse chromosome 2 on the hematopoietic and intestinal tumorigenesis.
J.Toxicol.Pathol., 17, 105-112, 2004.

Collaboration paper #7: Kuwahara, K., Fujimura, S., Takahashi, Y., Nakagata,N., Takemori, T.,Aizawa, S.,Sakaguchi, N.
Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses.
Proc. Natl. Acad. Sci. USA. 101: 1010-1015. 2004.

Collaboration paper #6: Oike, Y., Yasunaga, K., Ito, Y., Matsumoto, S., Maekawa, H., Morisada, T., Arai, F., Nakagata,N, Takeya, M., Masuho, Y., Suda, T.
Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration.
Proc. Natl. Acad. Sci. USA. 100: 9494-9499. 2003.

Collaboration paper #5: Kyuwa, S., Nishikawa, T., Kaneko,T, Nakashima, T., Kawano, K., Nakamura, N., Noguchi, K., Urano, T., Itoh, T., Nakagata,N. Experimental evaluation of cross-contamination between cryotubes containing mouse 2-cell embryos and murine pathogens in liquid nitrogen tanks.
Exp. Anim. 52: 67-70. 2003.

Collaboration paper #4: Noguchi H, Kaname T, Sekimoto T, Senba K, Nagata Y, Araki M, Abe M, Nakagata N, Ono T, Yamamura K, Araki K.
Naso-maxillary deformity due to frontonasal expression of human transthyretin gene in transgenic mice.
Genes Cells. 2002; 7(10):1087-98.

Collaboration paper #3: Noguchi H, Ohta M, Wakasugi S, Noguchi K, Nakamura N, Nakamura O, Miyakawa K, Takeya M, Suzuki M, Nakagata N, Urano T, Ono T, Yamamura K.
Effect of the intestinal flora on amyloid deposition in a transgenic mouse model of familial amyloidotic polyneuropathy.
Exp Anim. 2002 Jul;51(4):309-16.

Collaboration paper #2: Oike Y, Ito Y, Hamada K, Zhang XQ, Miyata K, Arai F, Inada T, Araki K, Nakagata N, Takeya M, Kisanuki YY, Yanagisawa M, Gale NW, Suda T.
Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells.
Blood. 2002; 100(4):1326-33.

Collaboration paper #1: Ohtsuka S, Takaki S, Iseki M, Miyoshi K, Nakagata N, Kataoka Y, Yoshida N, Takatsu K, Yoshimura A.
SH2-B is required for both male and female reproduction.
Mol Cell Biol. 2002; 22(9):3066-77.